阿呋唑嗪和坦索罗辛对输尿管结石的临床疗效研究  

Clinical efficacy of alfuzosin and tamsulosin on patients with ureteral calculus

作　　者：向云霞[1] 刘冰[1] 安恒庆[2] 彭红玉[1] 

机构地区：[1]新疆医科大学第一附属医院药学部,乌鲁木齐830011 [2]新疆医科大学第一附属医院泌尿中心,乌鲁木齐830011

出　　处：《中国临床药理学杂志》2016年第3期206-208,共3页The Chinese Journal of Clinical Pharmacology

基　　金：新疆医科大学第一附属医院药学专项基金资助项目(No.2012YX05)

摘　　要：目的 观察α受体阻滞药阿呋唑嗪和坦索罗辛对输尿管结石的临床疗效和安全性。方法 320例确诊为输尿管结石的患者随机分为试验组和对照组,各160例。试验组口服盐酸阿呋唑嗪缓释片,每次10 mg,每天1次,对照组口服盐酸坦索罗辛缓释胶囊,每次0.4 mg,每天1次,2组疗程均为4周。所有患者在治疗期间保持每日饮水2000~3000 m L。记录每例患者的结石位置、大小等,每位患者临床检查结石排出,或者经过临床医师会诊需要改为手术治疗的为记录和研究结束点。结果 试验组结石排出率为63.13%,结石排出时间为（9.43±1.34）d;对照组结石排出率为76.25%,结石排出时间为（8.48±1.66）d,差异有统计意义（P〈0.05）。试验组输尿管上、中、下段结石排出率分别为53.85%,60.87%,65.77%,对照组分别为52.38%,62.92%,83.93%;试验组上、中、下段结石排出时间（9.50±1.22）,（9.14±1.35）,（9.48±1.37）d,对照组分别为（9.45±1.44）,（8.76±1.03）,（8.32±1.74）d,试验组和对照组输尿管上段和中段结石的排出率与排石时间差异无统计学意义（P〉0.05）,下段结石排出率和排出时间差异有统计学意义（P〈0.05）。结论 坦索罗辛和阿呋唑嗪对输尿管上段和中段的结石排出率及排出时间无明显差异,对输尿管下段结石,坦索罗辛优于阿呋唑嗪。Objective To evaluate the clinical efficacy and safety of tam- sulosin and alfuzosin on patients with ureteral calculus. Methods A to- tal of 320 patients with ureteral calculus were randomly divided into test group and control group, each group 160 cases. Patients in test group were given hydrochloridc alfuzosin sustained - release tablets 10 rag, once a day. Patients in control group were given tamsulosin hydrochloride sustained release capsules 0. 4 rag, once a day. All patients were treated for 4 weeks. All patients were drank 2000 - 3000 mL water a day. Detai- ling record the site and size of stones of patients, and the record ended with removal of all clcui or operation. Results Stones discharge rate and calculi discharge time in test group were 63.13%, （9.43 _± 1.34） d, had significant difference with those in control group, which were 76.25＇% , （8.48 ± 1.66） d （P 〈 0.05）. Upper, middle and lower seg- ment stone discharge rate were 53.85%, 60. 87%, 65.77% in test group and 52. 38% , 62.92% , 83.93% in control group. Upper, mid- dle and lower section of stone discharge time were （9.50 ± 1.22）, （9.14±1.35）, （9.48 ±1.37） d in test group and （9.45 ±1.44）, （8.76± 1.03）, （8.32 ± 1.74） d in control group. There were nosignificant difference between the removal rate and time of middle and upper ureteral calculi （P 〉 0.05 ）, but there was a significant difference between the removal rate and time of lower ureteral calculi （P 〈 O. 05 ）. Conclusion There were no significant difference in the removal rate of middle and upper ureteral calculi between tamsulosin and alfuzosin. For the treatment of lower ureteral calculi, tamsulosin was superior to alfuzosin.

关 键 词：输尿管结石 坦索罗辛 阿呋唑嗪 

分 类 号：R693.4[医药卫生—泌尿科学] R983.2[医药卫生—外科学]