宫腔积液的处理方式与体外受精-胚胎移植的临床结局  

Treatment methods for endometrial cavity fluid and clinical outcomes of in vitro fertilization and embryo transfer

作　　者：高焕云[1,2] 姜宏[1] 步仰高[3] 周云[1] 

机构地区：[1]中国人民解放军第105医院生殖医学中心,安徽合肥230031 [2]蚌埠医学院研究生部,安徽蚌埠233030 [3]中国人民解放军第105医院妇产科,安徽合肥230031

出　　处：《中国妇幼保健》2016年第2期331-333,共3页Maternal and Child Health Care of China

基　　金：南京军区医学科技创新重点课题资助项目(ZD14)

摘　　要：目的探讨宫腔积液(ECF)的处理方式对体外受精-胚胎移植(IVF-ET)临床结局的影响。方法回顾性分析行IVF-ET助孕并伴有宫腔积液151个周期的临床资料,将取卵日子宫内膜线分离最大前后径(APD)<3 mm的患者分为未干预组,未对积液进行处理;将APD≥3 mm者分为干预组,于取卵日行积液负压引流。两组均于移植日再次行超声观察,未见积液者行新鲜周期胚胎移植,以随机抽取的同期无宫腔积液153个周期作为对照组,分别比较3组间临床妊娠率、胚胎着床率及流产率。结果未干预组移植日积液存在率为7.14%(3/42),干预组宫腔积液的再发生率为6.42%(7/109);3组间临床妊娠率、胚胎种植率、流产率差异均无统计学意义(P>0.05)。结论移植日宫腔少量积液者(APD<3 mm)积液多可自然消失,不影响IVF的临床结局;积液量较多(APD≥3 mm)者在取卵日行积液引流后也可获得较满意的临床结局。Objective： To investigate effects of treatment methods of endometrial cavity fluid（ ECF） on the clinical outcomes of in vitro fertilization and embryo transfer（ IVF-ET）. Methods Clinical data of 151 cases with ECF fertilized by IVF-ET were analyzed retrospectively. The patients with the maximal anterior-posterior diameter（ APD） 〈3 mm on the day of taking oocytes were assigned into non-intervention group without treatment of fluid; the patients with APD≥3 mm were assigned into intervention group,which were administrated negative pressure drainage on the day of taking oocytes. Both groups were examined by ultrasound on the day of embryo transfer,and those without ECF were administrated fresh cycle embryo transfer. Taking the randomly selected 153 cycles without ECF as control group,clinical pregnancy rates,implantation rates and abortion rates were compared among the three groups. Results The existence of ECF in non-intervention group on the day of taking embryo transfer was 7. 14%（ 3 /42）,and that in intervention group was 6. 42 %（ 7 /109）; the difference in the rates of clinical pregnancy,implantation and miscarriage among three groups had no statistical significance（ P〉0. 05）. Conclusion Fluid of small amount in endometrial cavity（ APD〈3 mm） will disappear on the day of embryo transfer with no effect on clinical outcomes of IVF;patients with large amount of fluid（ APD≥3 mm） will have satisfactory clinical outcomes providing fluid drainage on the day of taking oocytes.

关 键 词：体外受精-胚胎移植 宫腔积液 临床结局 

分 类 号：R715.9[医药卫生—妇产科学]