腹腔镜疝囊高位结扎修补兔腹股沟疝的研究  

The Study of Laparoscopic High Ligation for Repairing Inguinal Hernia on Rabbits

作　　者：杨喜光[1] 陈小勋[1] 向国安[2] 张达[3] 张兆明[1] 陈开运[2] 王汉宁[2] 

机构地区：[1]贵港市人民医院胃肠外科,广西贵港537100 [2]广东省第二人民医院普通外科 [3]西安市中心医院普通外科

出　　处：《华西医学》2016年第1期33-36,共4页West China Medical Journal

基　　金：吴阶平医学基金会临床科研资助基金(320675009106)~~

摘　　要：目的探讨腹腔镜修补兔腹股沟疝模型模拟小儿疝腹腔镜高位疝囊结扎术后修补组织的病理生理变化的可行性。方法健康新西兰雄兔32只行腹腔镜右侧疝囊高位结扎术,于术后第7、15、30、60天分别随机取8只兔观察腹腔情况,并测量右侧内环口破裂瞬间所能承受的抗腹压值;切除修补区域组织,行苏木精-伊红染色观察修补区域愈合情况。结果研究期内实验兔无死亡。术后均未发现肠粘连、肠梗阻、疝复发等并发症。实验兔在术后第7、15、30、60天腹股沟区承受抗压值分别为(42.69±6.98)、(69.31±6.52)、(102.64±7.91)、(106.53±7.54)mm Hg(1 mm Hg=0.133 k Pa)。组织切片观察结果显示:修补区域愈合符合慢性非细菌性创伤愈合过程。结论腹腔镜疝囊高位结扎术修补兔腹股沟斜疝是安全可靠的。Objective To survey the feasibility of laparoscopic high ligation for pediatric inguinal hernias by performing the surgery on rabbit models.Methods Laparoscopic high ligation was operated on 32 healthy New-Zealand male rabbits.Eight random rabbits were observed under laparoscope on the 7 th,15 th,30 th,and 60 th days after operation,and the anti-tension strength at the instant when hernial inner ring cracked was measured.Repair regions were resected.After HE-staining,the syzygial status of the repair regions were checked.Results None of the rabbits died during the research with no such complications as ankylenteron intestinal obstruction or hernia relapses after surgery.The antitension strength by the inguinal regions of the experimental rabbits after surgery on the 7 th,15 th,30 th,and 60 th days was respectively（42.69 ± 6.98）,（69.31 ± 6.52）,（102.64 ± 7.91）,and（106.53 ± 7.54）mmHg（1mmHg= 0.133kPa）.As for the pathological section observation,the agglutination of the repair region was consistent with reparative process of chronic nonbacterial inflammation.Conclusion The operation of laparoscopic high ligation for repairing inguinal hernia on rabbits is safe and reliable.

关 键 词：腹腔镜 动物实验 腹股沟疝 疝模型 疝囊高位 

分 类 号：R656.21[医药卫生—外科学]