N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮的合成及生物活性  

Synthesis and Biological Activity of N'-( 2-Hydroxy-5-Bromobenzoylamino )-2-Imino-4-Thiazolidinone

作　　者：金龙飞[1] 李培娟[1] 亢子珍 范昕[1] 张健[1] 

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2015年第4期15-18,共4页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：湖北省自然科学基金重点项目(2008CDA067)

摘　　要：以5-溴水杨酸为原料,将其与水合肼反应生成了5-溴水杨酰肼,再将硫氰酸钾与5-溴水杨酰肼反应合成了5-溴水杨酰基氨基硫脲,后者与溴代乙酸乙酯反应生成了终产物N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮.对化合物进行了熔点、IR、元素分析、1H NMR、13C NMR表征,并测试了其对生物体的抗炎活性和抗菌活性.结果表明:N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮具有较好的抗炎、抗菌活性.5-bromo- salicylicacid was used to synthesize 5-bromo-methyl salicylate,which further reacted with hydrazine hydrate to obtain 5-bromosalicylaldehyde hydrazide. The 5-bromosalicylaldehyde hydrazine then reacted with potassium thiocyanate to form 5-bromosalicylaldehydethiosemicarbazides, which finally reacted with ethyl bromoacetate proceededcatalytic to afford N’-（ 2-hydroxy-5-bromobenzoylamino）-2-imino-4-thiazolidinone. The structure of the final compound was characterized by IR,element analysis,1H NMR,and13 C NMR. The compound also showed good antiinflammatory and antibacterial activity.

关 键 词：N’-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮 表征 抗炎活性 抗菌活性 

分 类 号：TQ217[化学工程—有机化工]