沈阳地区275例白癜风患者血清抗酪氨酸酶IgG抗体及其亚类的检测与分析  

Detection and Analysis of Serum Anti-tyrosinase IgG and Its Sub-types in 275 Vitiligo Patients in Shenyang Area

作　　者：金宁[1] 李铁男[1] 刘文力[1] 程欣[1] 刘奕 贺莎 吴善东 

机构地区：[1]沈阳市第七人民医院皮肤科,辽宁沈阳110003 [2]杭州浙大迪迅生物基因工程有限公司,浙江杭州310052

出　　处：《中国皮肤性病学杂志》2016年第2期133-135,共3页The Chinese Journal of Dermatovenereology

基　　金：沈阳市科技计划项目(F14-158-9-10)

摘　　要：目的探讨白癜风患者血清抗酪氨酸酶Ig G抗体(TYR sIgG)及其4种亚类与白癜风疾病的关系。方法采用酶联免疫吸附法(ELISA)检测沈阳地区275例白癜风患者和50例健康人血清中抗酪氨酸酶Ig G抗体及其4种亚类的含量。结果白癜风组与健康对照组TYR sIgG的阳性率比较差异有统计学意义(P<0.01)。白癜风组中TYR sIgG亚类的阳性率为IgG3>Ig G1>Ig G4,≥2种TYR sIgG亚类同时阳性61例,占TYR sIgG阳性白癜风的51.26%(61/119)。白癜风男女患者TYR sIgG及其4种亚类的阳性率比较差异均无统计学意义。结论酪氨酸酶可能刺激白癜风患者免疫系统产生TYR sIgG,与白癜风发病有关,检测TYR sIgG可为自身免疫性白癜风的诊断和免疫治疗提供一种科学的依据。TYR sIgG主导亚类为IgG3和IgG1。Objective To investigate the relationship between the serum levels of anti-tyrosinase IgG antibody, its 4 subtypes of vitiligo patients and vitiligo. Methods The serum levels of anti-tyrosinase IgG antibody and its 4 subtypes of 275 vitiligo and 50 healthy controls in Shenyaug area were detected by ELISA. Results The comparison between the positive rates of TYR sIgG of vitiligo and the healthy controls had statistical signifieance（P 〈0. 01 ）. The positive rates of TYR sIgG subtypes of vitiligo were IgG3 〉 IgG1 〉 IgG4. More than 2 TYR sIgG subtypes positive cases were 61, being 51.26% of TYR sIgG positive vitiligo（61/119）. The positive rates of TYR sIgG and its 4 subtypes had no statistical significance between male and female vitiligo. Conclusion Tyrosinase may stimulate immune system of vitiligo patients to generate TYR sIgG, and have relationship with pathogenesis of vitiligo. Detection of TYR sIgG may supply a scientific and experimental evidence for diagnosis and immunotherapy of autoimmune vitiligo. The dominating subtypes of TYR sIgG were IgG3 and IgG1.

关 键 词：白癜风 抗酪氨酸酶IgG抗体 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]