柴胡鳖甲汤联合常规抗病毒治疗病毒性乙型肝炎疗效观察  

Curative Observation of Combining Qinghao Biejia Decoction with Conventional Antiviral Therapy in the Treatment of Viral Hepatitis B

作　　者：郭灿[1] 曾莉[1] 

机构地区：[1]成都市第五人民医院,四川成都611130

出　　处：《四川中医》2016年第1期124-126,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的：观察柴胡鳖甲汤联合常规抗病毒治疗病毒性乙型肝炎的临床效果。方法：将我院自2013年2月~2015年2月收治的80例病毒性乙型肝炎患者作为研究对象,按随机序贯法分为对照组与观察组2组,对照组给予常规抗病毒疗法,观察组则对照组基础上加用柴胡鳖甲汤,2组均连续治疗4周,比较治疗前后2组ALT（丙氨酸转氨酶）、AST（谷草转氨酶）水平的变化情况,统计2组临床疗效,观察2组治疗的安全性,统计2组中医症候积分的改善情况。结果：观察组显效12例,有效10例,好转3例,总有效率为87.5%,与对照组的50.0%对比差异有统计学意义（P〈0.05）;治疗后,观察组ALT、AST、中医积分分别为（42.3±21.5）IU/L、（39.4±19.8）IU/L、（7.0±2.2）分,与对照组相比差异有统计学意义（P〈0.05）;观察组治疗不良反应发生率为5.0%,与对照组的27.5%对比差异有统计学意义（P〈0.05）。结论：在病毒性乙型肝炎患者的临床治疗中,采用柴胡鳖甲汤联合常规抗病毒治疗方案,临床治疗有效率高,患者肝功能指标明显改善,且不良反应发生率低,安全性高,值得推广。Objective： To analyze the clinical effect of Qinghao Biejia Decoction combined with conventional antiviral thera- py for viral hepatitis B. Methods ： 80cases of patients with virus hepatitis B and admitted into the hospital during February 2013to February 2015were treated as the research objects. According to the random sequential method, the objects were divided into con-trolled group and observation group of 2groups. The controlled group was given conventional antiviral therapy while the observation group was additionally treated with Qinghao Biejia Decoction, based on the controlled group. Both of the 2groups received contin- uous treatment for 4weeks. The changes of ALT （ alanine aminotransferase） and AST （ aspartate aminotransferase） levels in the two groups were compared before and after treatment. The clinical efficacy of the two groups was statistically analyzed. The safety of the treatment in the two groups was observed. And the improvement of TCM syndrome integrals was statistically analyzed. Re- sults： In the observation group, there were 12markedly effective cases, 10effective cases and 3improved cases. The total effective rate was 87.5% and compared with 50. 0% in the controlled group, the difference was statistically significant （P〈0. 05）. After the treatment, ALT, AST and TCM integrals of the observation group respectively were （42. 3±21.5 ） IU/L, （39.4±19. 8 ） IU/ L and （7. 0±2. 2） points, which compared with the controlled group, the difference was statistically significant （P〈0. 05）. The incidence rate of adverse reactions in the observation group was 5.0%. And compared with 27.5% in the controlled group, the difference was statistically significant （P〈0. 05）. Conclusion ： In the clinical treatment of patients with viral hepatitis B, to adopt Qinghao Biejia Decoction combined with conventional antiviral therapy, the clinical effective rate is high. It can significantly im- prove the liver function indexes, with low incidence rate of adverse reacti

关 键 词：病毒性乙型肝炎 柴胡鳖甲汤 抗病毒 效果 

分 类 号：R512.62[医药卫生—内科学]