苗药果上叶镇咳、抗炎作用有效部位筛选  

Screening Effective Parts of Antitussive and Anti-inflammatory from Miao Medicine Guoshangye

作　　者：马四补[1,2] 隋艳华[1] 王绍辉[2] 刘同祥[2] 屈相玲[3] 

机构地区：[1]贵阳中医学院,贵州贵阳550002 [2]中央民族大学中国少数民族传统医学研究院,北京100081 [3]贵阳中医学院第二附属医院,贵州贵阳550003

出　　处：《贵阳中医学院学报》2016年第1期1-5,共5页Journal of Guiyang University of Chinese Medicine

基　　金：贵州省中医药管理局中医药;民族药科学技术研究项目;项目编号:QZYY-34;贵州省科技合作计划项目;项目编号:黔科合LH字[2015]7265号

摘　　要：目的:筛选苗药果上叶镇咳、抗炎作用的有效部位。方法:观察果上叶三种提取部位对小鼠氨水、二氧化硫引咳的镇咳作用;观察果上叶三种提取部位对二甲苯致小鼠急性炎症耳肿,腹腔毛细血管通透性,角叉菜胶致小鼠亚急性炎症足跖肿的抗炎作用。结果:果上叶石油醚提取部位、乙酸乙酯提取部位、水层提取部位对氨水、二氧化硫引咳及对二甲苯致小鼠耳肿胀、小鼠腹腔毛细血管通透性及角叉菜胶致足跖肿胀均有不同程度抑制作用。结论:果上叶乙酸乙酯提取部位中剂量镇咳、抗炎作用显著。Objective： To screen the effective parts of antitussive and anti-inflammatory fromMiao Medicine Guoshangye. Methods： The effect on alleviating cough was observed in mice with ammonia water or sulfur dioxide induced cough ; and the effect of extracts on xylene-induced ear edema, acetic acid induced vascular permeability and carrageenan-induced hind paw edema tests in mice were investigated. Results： The parts of petroleum ether, ethyl acetate and water extracts could decrease the cough frequency in mice with ammonia water or sulfur dioxide, inhibit ear swelling caused by Dimethyl benzene, carrageenan-induced hind paw edema model in mice and the increase of peritoneal capillary permeability induced by HAC. Conclusion： The ethyl acetate parts of Guoshangye has significant function of antitussive and anti-inflammatory effects.

关 键 词：苗药果上叶 镇咳作用 抗炎作用 筛选 

分 类 号：R285.6[医药卫生—中药学]