血清成纤维细胞生长因子23与慢性心力衰竭心室重构的相关性  

Correlation of serum FGF23 levels and ventricular remodeling in patients with chronic heart failure

作　　者：邢文[1] 赵春梅[1] 王德国[1] 

机构地区：[1]皖南医学院弋矶山医院老年科,安徽芜湖241001

出　　处：《临床心血管病杂志》2016年第1期36-39,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金资助(No:81200142)

摘　　要：目的:探讨慢性心力衰竭(CHF)患者血清成纤维细胞生长因子23(FGF23)浓度变化及其与心室重构参数的关系。方法:选取我院CHF患者209例(其中NYHAⅢ级组105例,NYHAⅣ级组104例)。酶联免疫吸附法(ELISA法)检测FGF23的浓度,超声心动图测定心脏结构参数并计算左心质量指数(LVMI)。分析FGF23浓度与心脏功能、心脏重构的相关性。结果:NYHAⅣ级组血红蛋白、尿酸、NT-proBNP、HDL、LDL、Na+、左室射血分数(LVEF)、LVMI与Ⅲ组有明显差别(P<0.05);NYHAⅣ级组血清FGF23浓度(855.28±338.94)ng/L显著高于Ⅲ级组(742.29±213.45)ng/L,P<0.05;血清FGF23浓度与LVMI、左室舒张末期内径(LVDd)、室间隔厚度(IVSd)、左室后壁厚度(PWT)呈正相关,r(LVMI)=0.237,r(LVDd)=0.163,r(IVSd)=0.241,r(PWT)=0.194,P<0.05,与LVEF呈负相关(r=-0.171,P<0.05)。结论:CHF患者NYHAⅣ级组血清中FGF23浓度较Ⅲ级组明显升高,FGF23浓度与CHF心室重构程度呈正相关。Objective：To investigate the changes of serum FGF23 concentration in patients with chronic heart failure（CHF）and the correlation of FGF23 and left ventricular remodeling.Method：209inhospitalized patients with CHF were included in this study（NYHA Class III=105cases,NYHA Class IV=104cases）.The concentration of FGF23 was detected by enzyme-linked immunosorbent assay（ELISA）.Echocardiography was used to assay cardiac structure parameters and calculate left ventricular mass index（LVMI）.The correlations of FGF23 levels and cardiac function,LVMI were analyzed.Result：There were significantly abnormal of hemoglobin,uric acid,NT-BNP,HDL,LDL,Na,LVEF,LVMI between NYHA Class IV and III group（P〈0.05）.Serum FGF23 was significantly higher in the NYHA Class IV group than in NYHA Class III group[（855.28±338.94）ng/L versus（742.29±213.45）ng/L,P〈0.05].Serum FGF23 was positively correlated with LVMI,LVDd,IVSd,PWT,r（LVMI）=0.237,r（LVDd）=0.163,r（IVSd）=0.241,r（PWT）=0.194,P〈0.05,and negatively correlated with left ventricular ejection fraction（r=-0.171,P〈0.05）.Conclusion：Serum FGF23 increased in inhospitalized patients with CHF and positive correlated with the extent of ventricular remodeling.

关 键 词：心力衰竭 成纤维细胞生长因子23 心室重构 左心质量指数 

分 类 号：R541.6[医药卫生—心血管疾病]