复方薤白胶囊对肺源性脓毒症痰瘀闭阻证脱机时间的影响  

The Influence of Compound Xiebai Jiaonang on the Time of Ventilator Weaning of Pulmonale Sepsis Phlegm and Blood Stasis Resistance Syndrome

作　　者：奚肇庆[1] 林浩[2] 

机构地区：[1]江苏省中医院,江苏南京210000 [2]南京中医药大学,江苏南京210000

出　　处：《中国中医急症》2016年第1期17-19,47,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家卫计委中医重点临床专科建设项目;江苏科技厅科技创业中心新药复方薤白胶囊研制项目(专利号:ZL02160139.9)

摘　　要：目的观察复方薤白胶囊对肺源性脓毒症痰瘀闭阻证脱机时间的疗效。方法将40例肺源性脓毒症患者随机分为治疗组与对照组各20例。治疗组在常规治疗基础上联合复方薤白胶囊,1周为1个疗程,观察2个疗程。观察、比较两组治疗前后中医证候、指脉氧、血常规的白细胞和红细胞、血氧分压和二氧化碳分压(PCO_2)、脱机时间等指标。结果治疗组中医综合疗效总有效率90.00%,对照组为75.00%。两组治疗后血白细胞计数(WBC)、氧饱和度(SPO_2)、氧分压(PO_2)升高,血红细胞计数(RBC)、PCO_2降低(P<0.01)。治疗组WBC、PCO_2治疗后改善情况优于对照组(P<0.01)。脱机时间治疗组明显短于对照组(P<0.01)。结论复方薤白胶囊可明显改善咳、痰、喘、气急等临床症状,改善指脉氧、血常规、PCO_2、脱机时间等指标,缩短脱机时间。Objective： To observe the effect of Compound Xiebai Jiaonang on the timing of ventilator weaning of pulmonale sepsis phlegm and blood stasis resistance syndrome. Methods： Randomized controlled clinical trials were divided into the treatment group 20 cases and the control group 20 cases. The treatment group,on the basis of conventional treatment of joint Compound Xiebai Jiaonang,received 2 weeks′ course. TCM symptoms were observed and compared before and after treatment,as well as the pulse oxygen,white blood cells and red blood cells,blood gas analysis of routine blood oxygen partial pressure and CO_2 partial pressure,the time of ventilator weaning,etc. Results： The TCM comprehensive curative effect of the treatment group was 90.00%（P〈0.01）.Compared with before treatment,WBC,SPO_2 and PO_2value increased,while RBCand PCO_2reduced（P〈0.01）. In the comparison between the treatment group and the control group after treatment,there were significant differences in WBC and PCO_2（P〈0.01）. The time of ventilator weaning of the treatment group was significantly less than that of the control group,with significant difference（P〈0.01）. Conclusion： Compound Xiebai Jiaonang can obviously improve clinical symptoms such as cough,phlegm,asthma,short of breath,the means of pulse oxygen,blood routine,PCO_2 and other indicators,and shorten the time of ventilator weaning.

关 键 词：复方薤白胶囊 肺源性脓毒血症 痰瘀闭阻证 脱机时间 中西医结合 

分 类 号：R563[医药卫生—呼吸系统]