维生素C联合阿托伐他汀钙对血液透析患者氧化应激与微炎症状态的影响  

Effect of vitamin C combined with atorvastatin calcium on oxidative stress and micro-inflammation in patients with hemodialysis

作　　者：鲍恩昊[1] 朱爱国[1] 王志宏[1] 

机构地区：[1]上海市浦东新区人民医院肾脏内科,上海201200

出　　处：《海南医学院学报》2016年第5期431-434,共4页Journal of Hainan Medical University

基　　金：上海市科技创新计划(12640114348)~~

摘　　要：目的:探讨维生素C联合阿托伐他汀钙对血液透析患者氧化应激与微炎症状态的影响。方法:选取92例血液透析患者并随机分为阿托伐他汀钙组(A组)和维生素C联合阿托伐他汀钙组(B组),选取同期30例健康体检志愿者作为C组,比较A、B两组治疗前后及C组氧化应激与微炎症状态各指标,主要包括丙二醛(MDA)、过氧化物歧化酶(SOD)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)。结果:A、B组MDA水平治疗前均显著高于C组,两组治疗后指标水平均显著低于治疗前,且B组指标水平变化更为显著,差异均有统计学意义(P<0.05);两组SOD水平治疗前均显著低于C组,治疗后指标水平显著高于治疗前,且B组指标变化更为显著,差异均有统计学意义(P<0.05);A、B组治疗前微炎症状态各指标水平均显著高于C组,治疗后两组水平较治疗前均显著下降,且B组下降更为显著,差异均有统计学意义(P<0.05)。结论:维生素C联合阿托伐他汀钙能有效改善血液透析患者氧化应激与微炎症状态,值得临床应用。Objective.. To discuss the effect of vitamin C combined with atorvastatin calcium on oxidative stress and mi- cro-inflammatory state in hemodialysis patients. Methods： A total of 92 hemodialysis patients admitted to hospital were ran- domly divided into atorvastatin calcium group （A） and vitamin C combined with atorvastatin calcium group （B）, with 30 healthy volunteers as group C of the same time. Group A and B before and after treatment as well as group C was compared in terms of the micro-inflammatory state and oxidative stress indexes, including malondialdehyde （MDA）, superoxide dismutase （SOD）, C-reactive protein （CRP）, interleukin-6 （IL-6）, tumor necrosis factor （TNF-a） levels. Results： For the MDA levels, group A and group B before treatment were significantly higher than group C（P〈0.05） ;after treatment both group A and B were significantly lower than before（P〈0.05）, and the change of group B was more significant. As for SOD levels, before treatment both group A and B were significantly higher than group C（P〈0. 05）;after treatment they were significantly lowerthan before（P〈0. 05） ,and group B changed more siqnificantly. Regarding micro-inflammatory indexes, group A and group B before treatment were significantly higher than group C, and decreased more significantly after treatment than before（P 0.05）, and group B decreased more significantly. Conclusions： Vitamin C combined with atorvastatin calcium can effectively im- prove hemodialysis patients oxidative stress and micro-inflammatory state, and is worthy of clinical application.

关 键 词：血液透析 维生素C 阿托伐他汀钙 氧化应激 微炎症状态 

分 类 号：R459.5[医药卫生—治疗学]