维生素B_(12)联合二甲双胍治疗2型糖尿病对同型半胱氨酸的影响  

Therapeutic effects of Vitamin B_(12) combined with metformin on type 2 diabetes patients and influence on homocysteine level

作　　者：耿娜[1] 祁辉[1] 刘虎[1] 

机构地区：[1]河北省保定市第一医院内分泌科,河北保定071000

出　　处：《海南医学院学报》2016年第5期444-446,共3页Journal of Hainan Medical University

基　　金：国家自然科学基金项目(81070641)~~

摘　　要：目的：观察分析维生素B12联合二甲双胍治疗2型糖尿病对同型半胱氨酸（Homocysteine）的影响。方法：选择2014年4月～2014年10月在河北省保定市第一医院治疗的92例2型糖尿病患者进行研究。将所有患者随机分为对照组（46例）和观察组（46例）。对照组给予二甲双胍进行治疗；观察组给予维生素B12联合二甲双胍进行治疗。最后统计分析两组的治疗效果，以及治疗前、后的维生素B12和同型半胱氨酸水平。结果：治疗1、6个月和1年后，观察组维生素B12水平明显高于对照组，差异有统计学意义（P〈0．05）；对照组同型半胱氨酸水平明显高于观察组，差异有统计学意义（P〈0．01）。结论：维生素B12联合二甲双胍对2型糖尿病患者进行治疗，可以显著控制患者体内同型半胱氨酸的增加，同时治疗效果明显，值得推广。Objective.. To observe and analyze the therapeutic effects of Vitamin B12 combined with metformin on type 2 diabetes patients and influence on homocysteine level. Methods.. A total of 92 cases of type 2 diabetes were selected in the First Hospital of Baoding for treatment from October 2014 to April 2014 were selected and randomly divided into control group （46 cases） and observation group （46 cases）. Patients were treated by metformin in control group. Patients were treated by Vita- min B12 combined with metformin in observation group. Finally, patient outcomes, as well as Vitamin B12 and homocysteine in patients before and after treatment were analyzed. Results~ Vitamin B12 levels of observation group were significantly higher than control group 1 month, 6 months, and 1 year after treatment（P〈0.05）. Homocysteine levels of control group were sig- nificantly higher than observation group when patients were treated after 1 month, 6 months, and 1 year （P〈0.05）. Conclu- sion： Vitamin Bl2 combined with metformin in type 2 diabetes treatment, can significantly inhibit increase of homocysteine showing great effects on this disease, and it＇s worthy of application in large scale.

关 键 词：维生素B12 二甲双胍 糖尿病 同型半胱氨酸 

分 类 号：R587.1[医药卫生—内分泌]