肾嫌色细胞癌115例临床及病理分析  

Clinical andpathological analysis of renal chromphobe cell carcinoma:a report of 115 cases

作　　者：周永强[1,2] 王尚乾[1] 鲍美玲[3] 秦超[1] 王增军[1] 

机构地区：[1]南京医科大学第一附属医院泌尿外科,江苏南京210029 [2]苏州市吴江区第一人民医院泌尿外科,江苏苏州215200 [3]南京医科大学第一附属医院病理科,江苏南京210029

出　　处：《现代泌尿外科杂志》2016年第1期12-15,共4页Journal of Modern Urology

基　　金：国家自然科学基金青年科学基金(No.81201571)

摘　　要：目的分析临床肾嫌色细胞癌(RCCC)患者的临床资料及病理结果,提高RCCC的诊治水平。方法回顾性分析自2008年12月至2014年12月我院收治的115例肾嫌色细胞癌患者的临床资料和病理结果,并进行随访了解患者复发、生存情况。结果术后病理均证实为肾嫌色细胞癌。3例患者分别于术后24、35、39个月因肿瘤转移死亡,其中1例为脑、肺转移、2例为腹腔内多发转移。复习该3例患者临床资料及病理结果,显示2例在诊断时即有肾静脉癌栓形成,1例伴有肉瘤样变,镜下观察到癌组织广泛坏死、出现肉瘤样分化、浸润性生长显著、瘤细胞核仁明显、核分裂像较多。结论 RCCC是一种具有特殊形态的少见肾癌类型,预后相对较好,通过病理及免疫组化能有效鉴别诊断,当出现静脉癌栓或肉瘤样变时提示预后不佳。Objective To explore the diagnosis and treatment of renal chromphobe cell carcinoma （RCCC）. Methods The clinical profiles and survival time of 115 RCCC cases treated during Dec. 2008 and Dec. 2014 were retrospectively analyzed. Results Postoperative pathological results confirmed the diagnosis of RCCC. Three patients died because of metastasis （t in brain, 2 in abdomen） in the 24th, 35th, and 39th month following surgery. The profiles and pathological results showed 2 of the 3 patients had vena cava cancer thrombus at the first diagnosis and 1 had sarcoma-like pathological appearance. Conclusions RCCC can be diagnosed by pathology and immunohistochemistry even though it is a morphologically distinctive uncommon subtype of RCC. The poor prognosis is always accompanied with vena cava cancer thrombus and sarcoma-like change.

关 键 词：肾嫌色细胞癌 预后 病理 

分 类 号：R692.9[医药卫生—泌尿科学]