基于尿样代谢组学的中药药效及毒性研究进展  

Research progress of pharmacodynamics and toxicity of traditional Chinese medicine based on urinary metabolomics

作　　者：唐丹丹[1] 袁圣钧 张男[1] 赵宇辉[1] 魏锋[2] 赵英永[1] 

机构地区：[1]西北大学生命科学学院,西安710069 [2]中国食品药品检定研究院中药民族药检定所,北京100050

出　　处：《药物分析杂志》2016年第1期1-8,共8页Chinese Journal of Pharmaceutical Analysis

基　　金：教育部"新世纪优秀人才计划"项目(NCET-13-0954);国家十二五"重大新药创制"专项(2014ZX09304307-002);国家自然科学基金(J1210063;81202909;81274025);国家创新训练项目(201310697004)

摘　　要：代谢组学主要是通过分析生物体受到外界刺激后产生的相对分子质量低的内源性代谢产物来推断生物体的生理病理状态。代谢组学研究的整体、动态特点与中医药的整体和辩证论治特点相吻合,代谢组学已应用于中药现代化研究,推动了中医药的发展。本文查阅国内外有关代谢组学在单味中药及中药复方中的药效以及毒性方面研究的文献,总结了代谢组学在中药现代化研究中的成果,为该方面的研究提供参考。Metabolomics is the study of holistic changes in the endogenous low molecular weight metabolites of living systems and their dynamic responses to external stimuli （ including pathological stimuli and drug treatments ） to understand physiopathological states. Holistic investigation of metabolomics is in agreement with the holistic thinking of traditional Chinese Medicine （ TCM ）. Metabolomic methods and technologies have been applied to the modernization of Chinese materia medica research and improved the development of TCM. Based on the literature, this paper introduced the application of metabolomics in the research of pharmacodynamics and toxicity mechanism of single TCM and compound TCM and summarized the achievement of metabolomics in modernization of TCM in order to provide a reference for future research in this field.

关 键 词：代谢组学 单味中药 复方中药 药效 毒性 氨基酸代谢 脂肪酸代谢 能量代谢 综述 

分 类 号：R917[医药卫生—药物分析学]