肺内皮多糖包被与急性肺损伤的研究进展  

Research progress on pulmonary endothelial gycocalyx and acute lung injury

作　　者：方辰[1] 张剑锋[1] 

机构地区：[1]广西壮族自治区广西医科大学第一附属医院急诊科,南宁530021

出　　处：《中华灾害救援医学》2016年第1期42-45,共4页Chinese Journal of Disaster Medicine

基　　金：国家自然科学基金项目(81360290);广西自然科学基金项目(2014GXNSFAA118195)

摘　　要：内皮多糖包被(endothelial glycocalyx,EG)位于血管内皮细胞腔面,由蛋白聚糖(proteoglycan,PG)、糖胺聚糖(glycosaminoglycan,GAG)、膜糖蛋白及血浆蛋白组成。肺血管内皮的多糖包被可阻止中性粒细胞黏附和外渗,并影响内皮通透性的活性调控。多糖包被在急性肺损伤(acute lung injury,ALI)的发生、发展过程中可能起着重要的作用。对多糖包被的保护或重构可能是急性肺损伤临床治疗的一个新思路。Located on the luminal surface of vascular endothelial cells, the endothelial glycocalyx is composed of proteoglycan, glycosaminoglycan, glycoproteins and a wide array of molecules from plasma. Pulmonary endothelial glycocalyx serves as a barrier to neutrophil adhersion and extravasation. And it also has an impact on the active regulation of endothelial permeability. Endothelial glycocalyx plays a pivotal role in acute lung injury. Protection or reconstruction of glycocalyx may prove to be a new therapeutic approach for acute lung injury.

关 键 词：多糖包被 内皮细胞 急性肺损伤 

分 类 号：R655.3[医药卫生—外科学]