肾脏磁共振梯度多回波-R_2*成像可行性研究  

Feasibility of multiple-echo GRE-R_2*to renals at 3.0 T MRI

作　　者：黄海波[1] 黄桂雄[1] 陈毓秀[2] 李大创[1] 孙熙勇 管俊[1] 覃明[1] 

机构地区：[1]解放军第303医院影像科,南宁530021 [2]武警陕西总队医院MR室,西安710054 [3]解放军第303医院移植科,南宁530021

出　　处：《磁共振成像》2016年第1期62-67,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：广西科学研究与技术开发计划项目(编号:桂科攻1298003-8-6)~~

摘　　要：目的探讨磁共振肾脏梯度多回波R_2*成像可行性。材料与方法应用3.0 T MR系统梯度多回波序列,分别扫描专用水模(含氯化锰盐酸混合液小瓶15只)、原位正常肾51例(A组)和移植正常肾22例(B组)志愿者,次月重复扫描专用水模、原位正常肾组,原始DICOM数据导入CMRtools软件测算获得水模各小瓶及肾皮髓质R_2*值。结果水模R_2*与其浓度直线相关(r=0.999,P=0.000),通过直线回归分析,得到R_2*与Ph C拟合直线斜率为0.008,截距为–0.050。实际与预测水模浓度组内相关系数(ICC)为0.999,重复扫描水模R_2*ICC为1,重复扫描水模R_2*差值与总体0比较无统计学意义(P>0.05)。原位和移植肾组间性别与年龄无统计学意义(P>0.05);原位肾双侧R_2*无统计学差异(P>0.05);原位肾皮髓质重复测量R_2*ICC分别为0.847和0.915,差值与总体0无统计学意义(P>0.05)。移植与原位正常肾R_2*无统计学差异(P>0.05),肾髓质R_2*显著高于皮质,差异有统计学意义(P<0.05)。结论磁共振梯度多回波R_2*成像评价肾氧合状态具有可行性,可为更多肾脏R_2*成像推广应用提供依据。Objective： To explore the feasibility of multiple-echo GRE- R2^＊ to renals at 3.0 T MRI. Materials and Methods： A MR phantom which includes fifteen vials containing 0.2—3.2 mmol/L manganese chloride in hydrochloric acid solution, 51 healthy vonlunteers（Group A） with kidneys in-situ and 22 normal renals（Group B）transplanted were scanned by 3.0 T MRI, repeated protocols to the phantom and group A with kidneys in-situ one month later. Both phantom and in-vivo renals R2^＊ were quantified by a well-trained physician using a CMR tools after MRI. Results：Phantom R2^＊ was linearly correlated with its concentration in vials（r=0.999, P=0.000）.Through the regressions procedure,a slope of 0.008 and an intercept of –0.050 were found. No statistic differences were found for R2^＊ value between the first and second scanning on phantom（P〉0.05）, The real and predicted concentration of phantom, R2^＊repeated scanning on phantom have a highly reliability respectively（ICC（concentration）=1,ICC（R2^＊）=0.999）. No statistic differences were found for gender and age between group A and B（P〉0.05）. No statistic differences were found for the cortical and medullary R2^＊ between left and right renal（P〉0.05）. No statistic differences were found for kidneys R2^＊ in group A between the first and second scanning（P〈0.05）, It showed a well reliability respectively（ICC（cortex）=0.847, ICC（medullation）=0.915）. No statistic differences were found for renal R2^＊ between group A and B（P〈0.05）. However,renal R2^＊ was dramatically higher in medullation than in cortex and there was statistic difference（P〈0.05）. Conclusions： With CMRtools, multiple-echo GRE protocol is feasible for evaluating oxygenation in kidneys at 3.0 T MRI, it could provide a reliable evidence for clinic application to renals.

关 键 词：肾脏 磁共振成像 诊断技术和方法 

分 类 号：R445.2[医药卫生—影像医学与核医学] R692[医药卫生—诊断学]