环境内分泌干扰物与代谢综合征关系研究进展  

Research progress in relationship between endocrine disrupting chemicals and metabolic syndrome

作　　者：杨雪松[1] 杨静[1] 许洁[1] 

机构地区：[1]遵义医学院公共卫生学院,贵州遵义563000

出　　处：《实用预防医学》2016年第2期247-249,共3页Practical Preventive Medicine

基　　金：国家自然科学基金(201381360439);贵州省教育厅青年基金(黔教合KY字[2013]198);贵州省卫生厅基金(gzwkj20131127);遵义医学院博士启动基金(ZMKD2012-002);遵义医学院招标课题(2013F-68);遵义医学院研究生实践活动基金(zy-ysh2015001);贵州省科技厅遵义医学院联合基金重点项目(黔科合LH字[2014]7543)

摘　　要：越来越多的实验和流行病证据表明多种环境内分泌干扰物(endocrine disrupting chemicals,EDCs)对代谢综合征的发生起作用。目前的研究认为其暴露与2型糖尿病(T2D)、高血压、肥胖、多囊卵巢综合症发生有关,大多数ECDs有拟雌激素样作用而干扰内分泌系统,而且对人体发育、生殖、神经、心血管、代谢免疫产生有害作用。日常生活中人们主要通过摄食、呼吸、皮肤吸收暴露环境内分泌干扰物,环境内分泌干扰物主要包括双酚A、壬基酚、邻苯二甲酸、二恶英以及类似物、多氯联苯。本文的重点讨论其代表物其对肥胖、2型糖尿病、多囊卵巢综合征(PCOS)发病的作用,依据近几年国内外的文献对这一领域的研究成果进行综述。There is an increasing experimental and epidemiological evidence that many kinds of endocrine disrupting chemicals （EI~） are contributing to metabolic syndrome. Recent studies show that exposure to EDCs is associated with the occurrence of type 2 diabetes mellitus, hypertension, obesity and polycystic ovary syndrome （PCOS）. Most EI）Cs have mimic estrogenic effects and can interfere with normal functions of endocrine system and play harmful roles in growth, reproduction, neurology, cardiova- sology, metabolism and immunity in humans. In daily life, human exposure to EDCs, which mainly include bisphenol A （BPA）, nonyphenol, phthalate, dixons and the likes, and polychlorinated biphenyls, occurs via ingestion of food, breath and skin expo- sure. This review mainly focuses on the role of a representative of EDCs, BPA, in the pathogenesis of obesity, type 2 diabetes mellitus and PCOS and summarizes its recent research advances based on literatures both at home and abroad.

关 键 词：环境内分泌干扰物 代谢综合征 2型糖尿病 高血压 肥胖 多囊卵巢综合征 

分 类 号：R589[医药卫生—内分泌]