Irisin与老年2型糖尿病  

Irisin and type 2 diabetes mellitus in the elderly

作　　者：黄湘琴[1] 曹娴[2] 黄勤[1] 

机构地区：[1]第二军医大学长海医院内分泌科,上海200433 [2]第二军医大学翔安干休所,上海200433

出　　处：《第二军医大学学报》2016年第1期72-76,共5页Academic Journal of Second Military Medical University

摘　　要：Irisin是一种新发现的肌源性糖基化多肽,能促使白色脂肪细胞解偶联蛋白表达,诱导脂肪小滴形成,增加线粒体密度,增加脂肪细胞氧耗,导致白色脂肪细胞棕色样变,促进β细胞再生,从而抑制肥胖和胰岛素抵抗的发生;Irisin还能增加脑源性神经营养因子,激活参与学习和记忆的基因,从而改善认知;还能延长端粒从而延缓衰老等。本文综述了Irisin与老年2型糖尿病的关系,以期为老年2型糖尿病的有效防治提供参考。Irisin is a newly discovered myogenic glycosylation of peptide which can promote expression of uncoupling protein in white fat cells, facilitate lipid droplet formation, increase mitochondrial density and oxygen consumption of fat cells, and results in the shift from white fat cells to brown fat cells and promotion of 13 cells regeneration, thus inhibiting the occurrence of obesity and insulin resistance. Meanwhile, Irisin can also increase brain-derived neurotrophic factor, activate genes involved in learning and memorizing, so as to improve cognition function. Furthermore, Irisin is also reported to mitigate aging by extending the length of telomeres. This paper reviewed the relationship between Irisin and type 2 diabetes in the elderly, hoping to provide reference for prevention and treatment of type 2 diabetes in the elderly.

关 键 词：老年人鸢尾素 2型糖尿病 Ⅲ型纤维蛋白域包含蛋白5 米色脂肪 脑源性神经营养因子 端粒 

分 类 号：R587.1[医药卫生—内分泌]