激光辅助孵化对种植失败患者冻融胚胎移植妊娠结局的影响  

Effect of laser-assisted hatching on outcome of frozen-thawed embryo transfer for patients with previous repeated implantation failure

作　　者：路新梅[1] 徐晨[1] 王亮[1] 孙宁霞[1] 章青[1] 关彭芳[1] 李文[1] 

机构地区：[1]第二军医大学长征医院生殖医学中心,上海200003

出　　处：《第二军医大学学报》2016年第1期106-110,共5页Academic Journal of Second Military Medical University

基　　金：上海市科委产学研重点专项(14DZ1942502)~~

摘　　要：目的探讨激光辅助孵化(laser-assisted hatching,LAH)对种植失败患者冻融胚胎移植(frozen-thawed embryo transfer,FET)周期妊娠结局的影响。方法 2012年5月至2013年12月在本中心接受辅助生殖治疗的97例胚胎种植失败患者,选取其124个FET周期并随机分为两组:孵化组(61个周期),胚胎移植前行LAH;未孵化组(63个周期),胚胎移植前未行辅助孵化。比较两组的临床妊娠率和胚胎种植率以及流产率、多胎率。结果孵化组的临床妊娠率(47.5%)、胚胎种植率(29.2%)均高于未孵化组(30.2%和19.0%),差异有统计学意义(P<0.05)。流产率、多胎率等结局指标在两组间的差异无统计学意义(P>0.05)。结论 LAH可明显提高种植失败患者FET周期临床妊娠率和胚胎种植率,改善临床结局。Objective To determine whether lase〉assisted hatching （LAH） can improve the clinical outcome of frozen- thawed embryo transfers （FET） for patients with previous repeated implantation failure. Methods A total of 97 infertility patients with previous repeated failure, who received assisted reproductive therapy in our in-vitro fertilization（IVF） center from May 2012 to December 2013, were included in this study. A total of 124 FET cycles were randomly divided into LAH group （LAH was performed before embryo transplantation, n=61） and non-assisted hatching group （LAH was not performed before embryo transplantation, n 63）. The clinical pregnancy rate,implantation rate, abortion rate and multiple pregnancy rate were compared between the two groups. Results The pregnancy rate （47.5% vs 30. 2% ,P〈0.05） and implantation rate （29.2% vs 19.0% ,P〈0.05） in the assisted hatching group were both significantly higher than those in the non-assisted hatching group. There were no significant differences between the two groups in abortion rate or multiple pregnancy rate（P〉0. 05）. Conclusion The LAH can increase the pregnancy and implantation rates and improve the outcome of IVF-ET in frozen-thawed embryo transfer cycles for patients with previous repeated failure.

关 键 词：冻融胚胎移植 激光辅助孵化 种植失败 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]