芬苯达唑合成工艺的改进  

Improved Synthesis of Fenbendazole

作　　者：严家庆[1] 

机构地区：[1]江苏宝众宝达药业有限公司,江苏南通226532

出　　处：《浙江化工》2016年第1期8-11,共4页Zhejiang Chemical Industry

基　　金：江苏省工程技术研究中心建设项目(BM2012497)

摘　　要：以间二氯苯、苯硫酚、氰胺基甲酸甲酯为主要原料,经过硝化、氨化、缩合、还原、环合五个步骤制备了芬苯达唑。雷尼镍用作加氢工艺催化剂,环合反应采用甲苯和水两相溶剂体系。产品总收率达63.6%,纯度为99.9%以上。工艺具有清洁环保,产品质量高,成本低廉等优点。In this paper,fenbendazole was prepared with 1,3-dichlorobenzene thiophenol and methyleyanocarbamate as the main raw material, via five steps of nitration ammoniation condensation reduction and cyclization.Raney nickel was used as catalyst in hydrogenation reducion .The solvent in cyclization was two- phase of toluene and water .The total yield of the product reached 63.6% and the purity was above 99.9%. The process has the advantages of clean environment, high quality and low cost.

关 键 词：芬苯达唑 还原 氰胺基甲酸甲酯 

分 类 号：S859.795[农业科学—临床兽医学]