2型糖尿病未合并冠心病患者B型脑钠肽与空腹血糖的相关性研究  

The relationship between plasma brain natriuretic peptide and fasting plasma glucose in type 2 diabetic patients without coronary heart disease

作　　者：何茜[1] 谭洪文 于瑞萍[1] 罗建华[1] 徐淑静[3] 范元硕[1] 

机构地区：[1]贵州省人民医院内分泌科,贵阳550002 [2]贵州省人民医院心内科,贵阳550002 [3]贵州医科大学附属医院内分泌科

出　　处：《中国糖尿病杂志》2016年第1期47-49,共3页Chinese Journal of Diabetes

基　　金：2015贵阳市科技计划项目(20151001号)

摘　　要：目的探讨T2DM未合并冠心病患者血浆B型脑钠肽（BNP）与FPG的相关性。方法选取经冠脉造影排除冠心病的T2DM患者175例,按照FPG水平分为〈7mmol/L组、7~9mmol/L组和〉9mmol/L组,检测各组BNP等指标。结果 FPG〈7mmol/L组与其他两组比较,BNP水平差异有统计学意义[（16.02±5.03）vs（14.98±4.73）,（14.12±4.65）pg/ml]（P〈0.01）。随着FPG水平的增高,BNP浓度降低。Pearson相关分析显示,BNP与FPG呈负相关（r=-0.775,P〈0.01）。多元线性回归分析显示,年龄、SBP、SUA、BMI、FPG、HbA1c是BNP的影响因素（P〈0.05）。结论 BNP可能参与了血糖调节。Objective To investigate the relationship between plasma brain natriuretic peptide （BNP） and FPG in type 2 diabetic patients without coronary heart disease. Methods A total of 175 T2DM patients were selected. Coronary heart disease was ruled out by coronary angiograghy. All thepatients were divided into 3 groups according to their FPG levels：FPG〈7 mmol/L group （n= 72）, FPG 7~9 mmol/L group （n=58）,and FPG〉9 mmol/L group （n=45）. BNP and FPG were measured in all groups. Results The plasma BNP levels were significantly different among the three groups [（16.02± 5.03）, （14.98 ± 4. 73）, （ 14.12 ± 4.65） pg/ml）] （P 〈 0. 01）. The BNP level was decreased with the increasing of FPG. The pearson correlation analysis showed that BNP was negatively correlated with FPG （r=-0. 775 ,P%0.01）. Multiple stepwise regression analysis showed that BNP was positively correlated with age,SBP,and SUA,but negatively correlated with BMI,FPG, and HbA1 c （P〈0. 05）. Conclusion The plasma BNP may participate in the regulation of blood glucose.

关 键 词：糖尿病 2型 冠心病 B型脑钠肽 空腹血糖 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]