O-羟丙基壳聚糖/聚乙二醇水凝胶的制备及其表征  

Preparation and Characterization of O-Hydroxypropyl Chitosan/Polyethylene Glycol Hydrogel

作　　者：谭福能[1] 

机构地区：[1]文山学院化学与工程学院,云南文山663099

出　　处：《文山学院学报》2015年第6期19-22,共4页Journal of Wenshan University

基　　金：云南省科技厅应用基础研究计划青年项目"新型壳聚糖衍生物智能凝胶的制备技术研究"(2012FD058)

摘　　要：以壳聚糖为原料,合成了两亲性O-羟丙基壳聚糖(O-HPCS),并以O-羟丙基壳聚糖(O-HPCS)和聚乙二醇(PEG)为原料制备羟丙基壳聚糖/聚乙二醇水凝胶,以傅里叶变换红外光谱(FTIR)对凝胶的结构进行了表征,通过正交实验研究了O-羟丙基壳聚糖浓度、聚乙二醇和O-羟丙基壳聚糖质量比、温度、交联剂戊二醛浓度对聚乙二醇/O-羟丙基壳聚糖水凝胶溶胀性能的影响,确定了最佳制备条件,研究了水凝胶的p H敏感性和温度敏感性。A novel of amphipathy O-hydroxypropyl chitosan （ O-HPCS ） is synthesized by modified chitosan. O-hydroxypropyl chitosardpolyethylene glycol（PEG） hydrogel is prepared via cross linking of O-hydroxypropyl chitosan and polyethylene glycol. This hydrogel is investigated by FTIR. The influence of concentration of O-HPCS, PEG and glutaraldehyde, reaction temperature on hydrogel performance are discussed through orthogonal experiment. Temperature sensibility and pH sensibility of O-HPCS/PEG hydrogel are investigated.

关 键 词：O-羟丙基壳聚糖 聚乙二醇 水凝胶 溶胀率 

分 类 号：O636.1[理学—高分子化学]