218例2岁以下儿童维生素D及骨密度营养状况分析  

Analysis of nutritional status for vitamin D and bone mineral density of 218 childen under 2 years old

作　　者：黄佳[1] 刘文兵[1] 徐小晶[1] 鲍雪梅[1] 刘维韦 陈迎建 

机构地区：[1]南通市妇幼保健院,江苏南通226006

出　　处：《中国妇幼健康研究》2015年第6期1116-1118,共3页Chinese Journal of Woman and Child Health Research

基　　金：江苏省南通市社会事业科技创新与示范项目(HS149006)

摘　　要：目的了解2岁以下儿童维生素D及骨密度营养状况及其影响因素。方法选取2014年1月至2014年12月就诊于南通市妇幼保健院儿童保健科的2岁以下儿童作为研究对象，采用酶联免疫法测定血清25-羟基维生素D[25-（OH）D]水平，定量超声仪测定骨密度。结果2岁以下儿童血清25-（OH）D水平为53．58±25．06nmol／L，骨密度z值水平为一0．37±1．11。男女童的骨密度z值有明显差异（t=2．322，P〈0．05）。1—2岁组骨密度z值明显高于0～〈1岁组（t=-12．173，P〈0．001），0-〈1岁组25·（OH）D水平明显高于1—2岁组（t=2．238，P〈0．05）。影响25-（OH）D水平的主要因素为户外活动时间、近3月是否补充维生素AD（VitAD）（OR值分别为8．732和0．035，均P〈0．001）；影响骨密度z值的主要因素为喂养方式、近3月是否补充钙剂（OR值分别为8．732和0．035，均P〈0．001）。结论2岁以下儿童维生素D水平普遍不足，其中，1～2岁组儿童更为严重；2岁以下儿童骨密度z值普遍正常。儿童保健科医师应加强有关佝偻病预防相关知识的宣教。Objective To investigate the nutritional status for vitamin D and bone mineral density （BMD） and their influencing factors of children under 2 years old. Methods Children under 2 years old who visited child healthcare department from January to December in 2014 were selected as the objects of study. Serum 25-（OH） D level was measured by ELISA, and individual BMD was measured by quantitative ultrasound. Results Serum 25-（OH） D level was 53.58 ＋ 25.06nmol/L and Z value of BMD was -0.37 ＋ 1.11. There was significant difference in Z value of BMD between boys and girls （ t = 2. 322, P 〈 0.05 ）. Z value of BMD in 1 - 2 years old group was significantly higher than that in 0 - 1 year old group （ t = - 12. 173, P 〈 0. 001 ）, while serum 25-（OH） D level in 0 - 1 year old group was significantly higher than that in 1 - 2 years old group （ t = 2.238, P 〈 0.05 ）. Time for outside activities and whether VitAD being added in the last 3 months were the main influencing factors of serum 25-（OH） D level （ OR value was 8. 732 and 0. 035, both P 〈 0. 001 ） , while feeding mood and whether calcium powder being added in the last 3 months were the main influencing factors of Z value of BMD （ OR value was 8. 732 and 0.035, respectively, both P 〈 0. 001 ）. Conclusion The serum vitamin D level is generally deficient, and it is worse in 1 - 2 years old group. The Z value of BMD is normal in children under 2 years old. Child heahhcare practitioners should spread knowledge on preventing rickets of vitamin D deficiency.

关 键 词：维生素D 骨密度 儿童 影响因素 

分 类 号：R179[医药卫生—妇幼卫生保健]