4-(吡咯烷-1-基磺酰基甲基)苯肼盐酸盐的工艺研究  

A Study on Technology of 4-(Pyrrolidine-1-Sulfonymethyl) Phenylhydrazine Hydrochloride

作　　者：马小双[1] 周云波[2] 苟丽[2] 

机构地区：[1]文山学院环境与资源学院,云南文山663099 [2]文山学院化学与工程学院,云南文山663099

出　　处：《文山学院学报》2015年第6期53-55,共3页Journal of Wenshan University

摘　　要：以氯化苄为起始原料,经硝化、磺酸化、氯化、氨解、还原、重氮化及还原共7步反应,合成阿莫曲坦中间体4-(吡咯烷-1-基磺酰基甲基)苯肼盐酸盐,总收率为19.4%。考察反应温度、时间、溶剂、催化剂用量等对反应的影响,为阿莫曲坦合成工艺提供参考。The intermediate 4-（pyrrolidine-1-sulfonymethyl） phenylhydrazine hydrochloride is prepared by using benzyl chloride as starting material via seven steps, including nitration, sulfonation, chloration, ammonolysis, reduction, diazotization and reduction will the overall yield of 19.4%. The effects of reaction temperature, time, solvent and catalyst amount on the reaction are investigated, Which provides a reference for the synthesis of almotriptan.

关 键 词：氯化苄 吡咯烷 钯炭 4-(吡咯烷-1-基磺酰基甲基)苯肼盐酸盐 阿莫曲坦 

分 类 号：TQ2[化学工程—有机化工]