重症肺炎患儿血清sICAM-1、CRP、FIB检测及临床意义  

Serum sICAM-1,CRP and FIB levels in children with severe pneumonia and their clinical significance

作　　者：党润 杨镒宇 

机构地区：[1]广州市妇女儿童医疗中心PICU,广东广州510120

出　　处：《中国妇幼健康研究》2015年第6期1210-1212,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨重症肺炎患儿血清可溶性细胞间粘附分子-l（sICAM-1）、C-反应蛋白（CRP）、纤维蛋白原（FIB）表达水平，分析其与重症肺炎的关系。方法选取广州市妇女儿童医疗中心收治的90例重症肺炎患儿为研究对象，另选取同期轻症肺炎患儿及健康体检儿童各90例，采用ELISA法测定slCAM-1，速率散射法检测CRP，全自动血凝分析仪测定FIB，比较各组间血清slCAM-1、CRP、FIB水平差异。结果重症肺炎组患儿发热时间、咳嗽时间、湿罗音持续时间、住院时间、呼吸频率均显著高于轻症肺炎组（t值分别为13．232、16．684、11．299、6．370、8．110，均P〈0．05）；治疗前siCAM．1、CRP、FIB水平重症肺炎组〉轻症肺炎组〉对照组（t=9．293-56．885，均P〈0．001），评估治疗效果方面slCAM-1、FIB连续动态监测优于CRP。结论血清slCAM-1、CRP、FIB水平可在一定程度上反映患儿肺炎严重程度，可作为重症肺炎患儿诊断及病情监测的参考指标。ObjectiveTo investigate serum soluble intercellular adhesion molecule-1 （sICAM-1）, C- reactive protein （CRP） and fibrinogen （FIB） expression levels in children with severe pneumonia and to analyze their correlation with severe pneumonia. Methods A total of 90 children with severe pneumonia were selected in Guangzhou Women and Children Medical Center. At the same period 90 children with mild pneumonia and 90 healthy children were selected. SICAM-1 was measured with ELISA, CRP was detected by scattering rate detection, and FIB was detected by automated coagulation analyzer. Serum sICAM-1, CRP and FIB levels were compared among different groups. Results Fever, cough time, crackles duration and hospitalization length in severe pneumonia group were significantly longer and respiratory rate was higher than mild pneumonia group （ t value was 13. 232, 16. 684, 11. 299, 6. 370 and 8.110, respectively, all P 〈 0.05 ）. Before treatment sICAM-1, CRP and FIB levels of severe pneumonia group were higher than those of mild pneumonia group, and those of mild pneumonia group were higher than control group （ t value ranged 9. 293 - 56. 885, all P 〈 0. 001 ）. Continuous dynamic monitoring of sICAM-1 and FIB was better than CRP in assessment of therapeutic effect. Conclusion Serum sICAM-1, CRP and FIB levels may reflect the severity of pneumonia to certain extend, and they can be used as reference indexes for diagnosis and monitoring severe pneumonia in children.

关 键 词：重症肺炎 血清可溶性细胞间粘附分子-1 C-反应蛋白 纤维蛋白原 

分 类 号：R725.6[医药卫生—儿科]