氟哌利多抑制吗啡成瘾大鼠尾核内p-CREB的表达  

Droperidol inhibits morphine-induced increase of p-CREB in the caudate nucleus of rats

作　　者：常金龙[1] 尹世琦[2] 刘晓宇[1] 王然[1] 王娇[1] 张颖[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150081 [2]黑龙江省电力医院内科,黑龙江哈尔滨150030

出　　处：《哈尔滨医科大学学报》2015年第6期486-488,共3页Journal of Harbin Medical University

基　　金：黑龙江省留学归国科学基金项目(LC2012C20)

摘　　要：目的探讨氟哌利多对吗啡成瘾大鼠尾核内磷酸化c AMP反应元件结合蛋白(p-CREB)表达的影响。方法大鼠皮下注射递增剂量吗啡,建立吗啡成瘾动物模型。然后侧脑室注射氟哌利多,用免疫组织化学方法测定尾核内p-CREB表达。结果大鼠吗啡成瘾后,尾核内p-CREB表达增加;侧脑室注射氟哌利多后,成瘾大鼠尾核内p-CREB表达降低。结论尾核参与吗啡成瘾的过程。氟哌利多抑制吗啡成瘾诱导的尾核内p-CREB表达。Objective To determine the effects of droperidol on the p-CREB expression in the caudate nucleus of morphine dependent rats. Methods A physical dependent model in rats was established by subcutaneous injection of morphine. Droperidol was injected into lateral ven- tricles. The levels of p-CREB in the caudate nucleus of morphine dependent rats were detected by immunohistochemistry method. Results The levels of p-CREB in the caudate nucleus of morphine dependent rats were increased. After the administration of droperidol, the expression of p-CREB in the caudate nucleus of morphine dependent rats was decreased. Conclusion The caudate nucleus maybe involves in the morphine dependence. Droperidol inhibits mor- phine-induced increase of p-CREB in the caudate nucleus.

关 键 词：吗啡 成瘾 尾核 CAMP反应元件结合蛋白 氟哌利多 

分 类 号：R338[医药卫生—人体生理学]