时辰药理学与临床合理用药的关系  

Relationship Between Chronopharmacology and Clinical Rational Drug Use

作　　者：王文文[1] 

机构地区：[1]河南省郑州市第七人民医院药学部,450016

出　　处：《中国卫生标准管理》2015年第32期91-92,共2页China Health Standard Management

摘　　要：时辰药理学是研究药理作用与昼夜节律关系的一门学科,结合临床需要,其能够为临床选择最佳用药时间提供参考。本文参考有关文献和资料,结合临床实际,从人体生物节律及药理学方面进行分析、汇总。同一种药物在一天中同等剂量、不同的给药时间,其疗效和毒性不同。根据机体自身的节律变化和药物的相互作用的时辰节律来选择最佳用药时间,确定给药方案,可提高疗效,还可减少药物的用量,并最大限度地减少不良反应的发生。The chronopharmacology is to study the pharmacological effects of pharmacology and the circadian rhythm of a subject relationship,combined with clinical need to choose the best time for clinical drug reference. Refer to the literature and information,clinical practice,and analysis from human biological rhythms and pharmacology. The same drug in the same dose a day,a different time of administration,had different efficacy and toxicity. According to the interaction of the body＇s own rhythm,hour rhythm changes and medications to choose the best treatment time determining the dosing regimen,you can improve efficacy,but also reduce the amount of drugs,and to minimize the incidence of adverse reactions.

关 键 词：时辰药理学 合理用药 最佳给药时间 

分 类 号：R96[医药卫生—药理学]