2-甲氧基雌二醇缓控释制剂的体外释药研究  

The Study on Release Characteristics of 2-methoxyestradiol in Vitro of Targeted Delivery System

作　　者：李艳凤[1] 

机构地区：[1]郑州市第七人民医院药学部,450016

出　　处：《中国卫生标准管理》2015年第32期136-137,共2页China Health Standard Management

摘　　要：目的考察2-甲氧基雌二醇缓控释制剂的体外释药情况。方法按照2010年版《中华人民共和国药典》规定的第一法,分别在p H 7.4及p H 5.5的释药介质中考察2-甲氧基雌二醇缓控释制剂的体外释药情况。结果在p H 7.4及p H 5.5释药介质中,与2-甲氧基雌二醇溶液对照组相比,所制备缓控释制剂均显示出缓释效果且在p H 5.5释药介质中释药相对较快。结论制备的制剂具有缓控释特性及对肿瘤靶部位的选择性。Objective Study the release characteristics of 2-methoxyestradio in vitro of targeted delivery system. Methods According to the first method of the＂pharmacopoeia of the People＇s Republic of China＂（2010）. In vitro drug release were carried out in the p H 7.4 and p H 5.5 dissolution medium. Results Compared with the control group,the preparation released slowly and released quickly relatively in p H 5.5 dissolution medium. Conclusion The preparation has a sustained release characteristic and tissue targeting selectively in tumour.

关 键 词：2-甲氧基雌二醇 缓控释 体外释药 

分 类 号：R94[医药卫生—药剂学]