Association between endothelial nitric oxide synthase(ENOS) G894T polymorphism and high altitude(HA) adaptation： a meta-analysis  

作　　者：Hong-xiang LU Yu-xiao WANG Yu CHEN Yong-jun LUO 

机构地区：[1]Department of Military Medical Geography [2] College of High Altitude Military Medicine, the Third Military Medical University, Chongqing 400038, China [2]Battalion 5 of Cadet Brigade, the Third Military Medical University, Chongqing 400038, China [3]Key Laboratory of High Altitude Medicine (Ministry of Education) [5] the Third Military Medical University, Chongqing 400038, China

出　　处：《中国应用生理学杂志》2015年第6期517-523,共7页Chinese Journal of Applied Physiology

基　　金：supported by the National Natural Science Foundation of China(81372125)

摘　　要：Objective: Highland natives adapt well to the hypoxic environment at high altitude(HA). Several genes have been reported to be linked to HA adaptation. Previous studies showed that the endothelial nitric oxide synthase(ENOS) G894 T polymorphism contributed to the physiology and pathophysiology of humans at HA by regulating the production of NO. In this meta-analysis, we evaluate the association between the ENOS G894 T polymorphism and HA adaptation through analyzing the published data. Methods: We searched all relevant literature about the ENOS G894 T polymorphism and HA adaptation in Pub Med, Medline, and Embase before Step 2015. A random-effects model was applied(Revman 5.0), and study quality was assessed in duplicate. Six studies with 634 HA native cases and 621 low-altitude controls were included in this meta-analysis. Results: From the results, we observed that the wild-type allele G was significantly overrepresented in the HA groups(OR=1.85; 95% CI, 1.47–2.33; P<0.0001). In addition, the GG genotype was significantly associated with HA adaptation(OR=1.99; 95% CI, 1.54–2.57; P<0.0001). Conclusion: Our results showed that in 894 G allele carriers, the GG genotype might be a beneficial factor for HA adaptation through enhancing the level of NO. However, more studies were needed to confirm our findings due to the limited sample size.Objective： Highland natives adapt well to the hypoxic environment at high altitude（HA）. Several genes have been reported to be linked to HA adaptation. Previous studies showed that the endothelial nitric oxide synthase（ENOS） G894 T polymorphism contributed to the physiology and pathophysiology of humans at HA by regulating the production of NO. In this meta-analysis, we evaluate the association between the ENOS G894 T polymorphism and HA adaptation through analyzing the published data. Methods： We searched all relevant literature about the ENOS G894 T polymorphism and HA adaptation in Pub Med, Medline, and Embase before Step 2015. A random-effects model was applied（Revman 5.0）, and study quality was assessed in duplicate. Six studies with 634 HA native cases and 621 low-altitude controls were included in this meta-analysis. Results： From the results, we observed that the wild-type allele G was significantly overrepresented in the HA groups（OR=1.85; 95% CI, 1.47–2.33; P〈0.0001）. In addition, the GG genotype was significantly associated with HA adaptation（OR=1.99; 95% CI, 1.54–2.57; P〈0.0001）. Conclusion： Our results showed that in 894 G allele carriers, the GG genotype might be a beneficial factor for HA adaptation through enhancing the level of NO. However, more studies were needed to confirm our findings due to the limited sample size.

关 键 词：内皮型一氧化氮合酶 ENOS 多态性 HA 高海拔 高原低氧环境 MEDLINE 病理生理学 

分 类 号：S823.85[农业科学—畜牧学] Q55[农业科学—畜牧兽医]