Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats  

作　　者：Bo MENG Lu-lu SHEN Xiao-ting SHI Yong-sheng GONG Xiao-fang FAN Jun LI Hong CAO 

机构地区：[1]Department of Anesthesiology, the 2nd Affiliated Hospital of Wenzhou Medical University [2]Teaching Center of Medical Functional Experiment, Wenzhou Medical University

出　　处：《中国应用生理学杂志》2015年第6期541-548,共8页Chinese Journal of Applied Physiology

基　　金：supported by a grant from the National Natural Science Foundation of China(No.81073125);Natural Science Foundation of Zhejiang Province(Y2090252)

摘　　要：Along with the development of economy and society, type 2 diabetic mellitus(T2DM) has become one of the most common diseases at the global level. As one of the complications of T2 DM, diabetic neuropathic pain(DNP) stubbornly and chronically affects the health and life of human beings. In the pain field, dorsal root ganglion(DRG) is generally considered as the first stage of the sensory pathway where the hyperexcitability of injured neurons is associated with different kinds of peripheral neuropathic pains. The abnormal electrophysiology is mainly due to the changed properties of voltage-gated sodium channels(VGSCs) and the increased sodium currents(INa). Curcumin is an active ingredient extracted from turmeric and has been demonstrated to ameliorate T2 DM and its various complications including DNP effectively. The present study demonstrates that the INa of small-sized DRG neurons are significantly increased with the abnormal electrophysiological characteristics of VGSCs in type 2 diabetic neuropathic pain rats. And these abnormalities can be ameliorated efficaciously by a period of treatment with curcumin.Along with the development of economy and society, type 2 diabetic mellitus（T2DM） has become one of the most common diseases at the global level. As one of the complications of T2 DM, diabetic neuropathic pain（DNP） stubbornly and chronically affects the health and life of human beings. In the pain field, dorsal root ganglion（DRG） is generally considered as the first stage of the sensory pathway where the hyperexcitability of injured neurons is associated with different kinds of peripheral neuropathic pains. The abnormal electrophysiology is mainly due to the changed properties of voltage-gated sodium channels（VGSCs） and the increased sodium currents（INa）. Curcumin is an active ingredient extracted from turmeric and has been demonstrated to ameliorate T2 DM and its various complications including DNP effectively. The present study demonstrates that the INa of small-sized DRG neurons are significantly increased with the abnormal electrophysiological characteristics of VGSCs in type 2 diabetic neuropathic pain rats. And these abnormalities can be ameliorated efficaciously by a period of treatment with curcumin.

关 键 词：背根神经节神经元 2型糖尿病 姜黄素 钠电流 神经痛 大鼠 DRG神经元 电压门控钠通道 

分 类 号：Q421[生物学—神经生物学] Q75[生物学—生理学]