2-呋喃甲醛-4-羟基苯甲酰腙及其Cu(Ⅱ)配合物的晶体结构及与CT-DNA的结合性能  

2-Furancarbaldehyde-4-hydroxy-benzoylhydrazone and Its Cu(Ⅱ) Complex:Crystal Structures and Binding Ability with CT-DNA

作　　者：刘向荣[1] 孙秀超[1] 杨再文[1] 赵顺省[1] 杨水兰[1] 闫森[1] 

机构地区：[1]西安科技大学化学与化工学院,西安710054

出　　处：《无机化学学报》2016年第2期250-258,共9页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金项目(No.21073139;21301139;21103135);陕西省自然科学基础研究计划项目(No.2015JQ2043)资助

摘　　要：通过2-呋喃甲醛与4-羟基苯甲酰肼缩合得到2-呋喃甲醛-4-羟基苯甲酰腙(H2L),并以其为配体与Cu(Ⅱ)配位得到了配合物[Cu(HL)2]·2H2O(1),采用元素分析和X射线单晶衍射对配体和配合物进行结构表征,结果表明配体属于正交晶系,Pna21空间群。配合物属于单斜晶系,P21/c空间群。利用热重实验研究了H2L和1的热稳定性,并计算了它们主要热分解过程的表观活化能,发现H2L和1的热稳定性都较高。通过紫外吸收光谱研究了H2L和1与CT-DNA的相互作用方式,并利用微量热计测量了其作用过程的热效应,结果表明H2L和1均以插入方式与CT-DNA结合,且作用过程放出的热量1大于H2L,说明配合物与CTDNA的结合能力强于配体。2-furancarbaldehyde-4-hydroxy-benzoylhydrazone （H2L） was synthesized from 4-hydroxybenzoylhydrazine and 2-furancarbaldehyde, and its Cu（Ⅱ） coordination polymer [Cu（HL）2] ·2H2O （1） also was prepared. H2L and 1 were characterized by elemental analysis and single crystal X-ray diffraction analysis. The crystal structural analyses show that the crystal of H2L belongs to orthorhombic system space group Pna21, and the crystal of 1 crystallizes in monoclinic system space group P21/c. Thermal gravity analyses were used to investigate the thermal stabilities of H2L and 1, and their apparent activation energy of the decompositions were also calculated. It was found that both of the complex and the ligand possessed higher thermal stability. The binding modes of H2L and 1 with CT-DNA were studied by UV-Vis absorption, and their interaction enthalpies were measured by microealorimetry. The results showed that the interaction of H2L and 1 with CT-DNA belonged to partial intercalation mode and 1 presented stronger interaction with CT-DNA than HzL. CCDC： 1030242, H2L; 1401955, 1.

关 键 词：酰腙化合物 Cu(Ⅱ)配合物 晶体结构 CT-DNA 微量热 

分 类 号：O614.121[理学—无机化学]