温和条件下制备形貌可控的羟基磷灰石（英文）  

Morphologically Controlled Synthesis of Hydroxyapatite at Mild Conditions

作　　者：肖鑫礼[1] 孔德艳[1] 张巨生[1] 

机构地区：[1]哈尔滨工业大学化学系,哈尔滨150001

出　　处：《无机化学学报》2016年第2期289-296,共8页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.51402073);中国博士后科学基金(No.2013M531030);中央高校基本科研业务费专项资金(No.HIT.NSRIF.2012064;2011018)资助项目

摘　　要：在温和条件下采用简单的实验方法成功制备出不同结构和形貌的羟基磷灰石(HAP)纳米粒子。采用沉淀-水解两步法,以PEG和PVP为表面活性剂,在沉淀步骤制备出前驱体CaHPO_4粒子,然后在100℃、常压条件下水解获得高结晶度的HAP纳米棒。采用PEG制备的纳米棒形貌均匀、纵横比高;采用PVP制备的纳米棒尺寸范围较宽且尺寸较小。直接采用一步沉淀法也能够成功制备出HAP纳米粒子。采用PEG制备出麦穗状的纳米粒子;采用PVP制备出尺寸小的纳米棒和纳米粒子混合物。HAP纳米晶的结构和形貌因制备条件不同发生很大变化,故而控制其合成,有望用于生物医药领域。Simple methods are introduced to obtain hydroxyapatite（HAP, Ca10（PO4）6（OH）2） nanocrystals with different structures and morphologies at mild conditions. The precipitation-hydrolysis two-step method can produce CaHPO4 precursor by assistance of polyethylene glycol （PEG） and polyvinylpyrrolidone （PVP） during the precipi- tation step, and the hydrolysis of CaHPO4 at 100 ℃ under atmospheric pressure leads to the formation of highly crystalline rod-like HAP nanocrystals. The HAP nanorods prepared with PEG possess uniform morphology with high aspect ratio while those prepared with PVP have smaller size with broader size distribution. One-step precipitation method can produce HAP directly, and the nanocrystals prepared with PEG are like wheat ears, while those prepared with PVP were composed of small nanoparticles and nanorods. The morphology of HAP samples was influenced by the organic additives, because the surfactants stabilized and confined the formation and growth of HAP nanocrystals. The morphology and structure of HAP nanoparticles changed greatly via the difference synthetic methods. Therefore, the controlling synthesis of HAP can be achieved by the change of synthetic conditions. The obtained HAP nanoparticles will be applicable for the future biomedical applications.

关 键 词：沉淀水解法 一步沉淀法 形貌控制 羟基磷灰石 

分 类 号：TB34[一般工业技术—材料科学与工程]