冠状病毒的氨基肽酶N受体的研究进展  

Review of aminopeptidase N as the receptor of coronavirus

作　　者：陈杰[1] 黄小波[1] 张雨迪 卿盈 李亚青[1] 文心田[1] 曹三杰[1] 文翼平[1] 伍锐[1] 

机构地区：[1]四川农业大学动物医学院,猪病研究中心/动物传染病与基因芯片室,成都611130

出　　处：《中国人兽共患病学报》2016年第1期89-94,共6页Chinese Journal of Zoonoses

摘　　要：氨基肽酶N(Aminopeptidase N,APN)是一种锌离子依赖性膜结合II型的金属跨膜糖蛋白,其广泛存在于人和哺乳动物的多种组织细胞中。APN是多种冠状病毒的黏附性受体,参与冠状病毒的粘附与侵袭,与病毒感染密切相关。本文对多种冠状病毒(HCoV-229E、FCoV、CCoV、TGEV、PEDV)的APN受体的结构、功能、抑制剂等研究进展进行了总结,重点介绍了其作为人和猪冠状病毒功能受体的进展。本文为深入研究和应用冠状病毒APN受体提供参考。Aminopeptidase N（APN）, a type II transmembrane glycoprotein that belongs to zinic-dependent membranebound metallopretease family, exists in many tissues of human and mammals as the binding-receptor of coronavirus. Participating in the coronavirus adhesion and invasion, aminopeptidase N is closely related to the coronavirus infection. In this essay, there is an overview of structure, function and inhibitors of aminopeptidase N that as functional receptor of HCoV-229E, FCoV, CCoV, TGEV, PEDV. This paper mainly introduces the progress of aminopeptidase N as functional receptors of human and swine coronavirus, so as to provide a reference to further research and application of APN receptor.

关 键 词：氨基肽酶N 冠状病毒 受体 

分 类 号：S855.3[农业科学—临床兽医学]