2型糖尿病患者血清胱抑素C水平与振动感觉阈值的关系  

Relationship between serum cystatin-C levels and vibrating perception threshold in patients with Type 2 diabetes mellitus

作　　者：晏丕军[1] 张志红[1] 徐勇[1] 万沁[1] 马红艳[1] 何建华[1] 

机构地区：[1]泸州医学院附属医院内分泌科,四川泸州646000

出　　处：《中南大学学报（医学版）》2016年第1期58-64,共7页Journal of Central South University ：Medical Science

基　　金：四川省科技厅基金(14JC0158);泸州市科技局基金[2013-S-48(22/30)];泸州医学院科研项目(2012QN-29);泸州医学院附属医院科研(12295)~~

摘　　要：目的:探讨2型糖尿病(Type 2 diabetes mellitus,T2DM)患者血清胱抑素C(cystatin-C,Cys-c)与振动感觉阈值(vibrating perception threshold,VPT)之间的关系。方法:选择352例T2DM患者,根据症状、体征和实验室检查分为神经病变组(DPN组,n=107)和非神经病变组(NDPN组,n=245),采用放射免疫分析法测定血清Cys-c水平,分析Cys-c与VPT,预估肾小球滤过率(estimated glomerular filtration rate,e GFR)﹑尿微量白蛋白/肌酐(urinary albumin-tocreatinine ratio,ACR)和血糖血压等指标的关系。将T2DM患者以Cys-c上四分位为切点分为高Cys-c组(n=89)和低Cys-c组(n=263),比较两组间神经病变患病率及VPT水平。应用Binary logistic回归分析T2DM患者发生周围神经病变的危险因素。采用受试者工作特征(receiver operating characteristic,ROC)曲线评估Cys-c预测T2DM患者发生周围神经病变的最佳界值。结果:DPN组血清Cys-c水平明显高于NDPN组(1.04±0.43 vs 0.80±0.25 mg/L,P<0.01)。T2DM患者血清Cys-c与年龄,体质量指数(body mass index,BMI),血肌酐(serum creatinine,SCr),血尿素氮(bloold urea nitrogen,BUN),ACR,VPT﹑脉压(pulse pressure,PP),白细胞计数(white blood count,WBC),红细胞分布宽度(red blood cell distribution width,RDW),糖化血红蛋白(hemoglobin A1c,Hb A1C)和空腹血糖(fasting blood glucose,FBG)呈正相关(分别r=0.410,0.115,0.613,0.433,0.291,0.300,0.156,0.129,0.282,0.314,0.236,分别P<0.05或P<0.01);与舒张压(diastolic pressure,DBP),e GFR和间接胆红素(indirect bilirubin,IBIL)呈负相关(r=-0.135,-0.647,-0.114,分别P<0.05或P<0.01)。校正性别,年龄,BMI,ACR和e GFR后,T2DM患者Cys-c与VPT仍呈明显正相关(r=0.235,P<0.01)。VPT,年龄,SCr﹑e GFR,PP,ACR和Hb A1C是影响T2DM患者血清Cys-c水平的独立相关因素。高Cys-c组周围神经病变患病率和VPT水平明显高于低Cys-c组(均P<0.01)。Logistic回归分析显示年龄、Cys-c和Hb A1C是预测T2DM患者周围神经病变发病的独立危险因素(均P<0.01)。ROC曲线显�Objective： To explore the relationship between serum cystatin-C （Cys-c） levels and vibrating perception threshold （VPT） in patients with Type 2 diabetes mellitus （T2DM）. Methods： According to the symptoms, signs and results of lab examination, a total of 352 patients with T2DM were divided into a diabetic peripheral neuropathy group （DPN group, n=107） and a non-diabetic peripheral neuropathy group （NDPN group, n=245）. Serum Cys-c levels were measured by radioimmunoassay method. The relationship between serum Cys-c levels and VPT, estimated glomerular filtration rate （eGFR）, urinary albumin-to-creatinine ratio （ACR）, glucose and blood pressure and other parameters were also analyzed by correlation and multiple regression analysis. All T2DM patients were divided into a high Cys-c levels group （n=89） and a low Cys-c levels group （n=263） according to the upper quartile of Cys-c, and the incidence of DPN and VPT levels in each group were compared. Risk factors of DPN in T2DM patients were analyzed by binary logistic regression analysis and receiver operating characteristic （ROC） curve was used to identify the optimal cutoff of serum Cys-c levels for predicting DPN in patients with T2DM. Results： Serum Cys-c levels were significantly higher in the DPN group than that in the NDPN group [（1.04±0.43） vs （0.80±0.25） mg/L, P〈0.01]. Correlation analysis showed that serum Cys-c levels were positively correlated with age, body mass index （BMI）, serum creatinine （SCr）, blood urea nitrogen （BUN）, ACR, VPT, pulse pressure （PP）, white blood cell（ WBC） , red cell distribution width （RDW）, hemoglobin A1c （HbA1c） and fasting blood glucose （FBG） （r=0.410, 0.115, 0.613, 0.433, 0.291, 0.300, 0.156, 0.129, 0.282, 0.314, 0.236, respectively, P〈0.05 or P〈0.01）; and negatively correlated with diastolic blood pressure （DBP）, eGFR and indirect bilirubin （IBIL） （r=？0.135, ？0.647, ？0.114, respectively, P〈0.05 or P〈0.01）. Serum

关 键 词：胱抑素C 振动感觉阈值 糖尿病肾病 氧化应激 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]