1例肾脏轻-重链沉积病患者的诊治  

A case of light and heavy chain deposition disease

作　　者：陈娴[1] 龙跃良 朱笑萍[1] 李军[1] 刘虹[1] 袁曙光[1] 周乐天[1] 

机构地区：[1]中南大学湘雅二医院肾内科,长沙410011 [2]安化县中医院肾内科,湖南安化413500

出　　处：《中南大学学报（医学版）》2016年第1期109-112,F0003,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81300567);湖南省科技厅院士基金(2013FJ4072);中华医学会临床医学科研专项资金项目(15020130601)~~

摘　　要：单克隆免疫球蛋白沉积病是一种少见病,肾脏为其最常累及的器官,主要以单克隆免疫球蛋白在基底膜沉积为特点,而轻重链沉积病则更为罕见,容易漏诊。2014年12月中南大学湘雅二医院肾内科收治1例经肾活检诊断的轻-重链沉积病男性患者,予以波尼松、马法兰及沙利度胺治疗后尿蛋白明显减少,肾功能好转。现对该例患者的诊断和治疗进行回顾性分析,以加强对此类疾病的认识,以便早期诊断,改善患者的预后。Monoclonal immunoglobulin deposition disease is rare in medical practice. The light and heavy chain deposition disease is characterized by deposition of monoclonal antibodies in the basement of membrane. Kidney is the most frequently involved organ. There was a male patient diagnosed as light and heavy chain deposition disease in department of Nephrology of the Second Xiangya Hospital, Central South University by renal biopsy. After treatment by oral prednisone, melphalan and thalidomide, the patient’s proteinuria and serum creatinine decreased. The retrospective analysis of this case provides a guide for doctors to understand the light and heavy chain deposition disease. Early diagnosis and treatment could improve the prognosis.

关 键 词：单克隆免疫球蛋白沉积病 轻重链沉积病 M蛋白血症 肾活检 

分 类 号：R692[医药卫生—泌尿科学]