长方案IVF/ICSI周期中获卵数与助孕结局的关系  

Relationship between Numbers of Retrieved Oocytes and Outcomes of Assisted Reproduction in IVF/ICSI Cycles

作　　者：倪佳[1] 黄静[1] 何钰辉[1] 柳胜贤[1] 

机构地区：[1]郑州大学附属洛阳中心医院,河南洛阳471000

出　　处：《中国医学创新》2015年第33期92-94,共3页Medical Innovation of China

摘　　要：目的：研究和分析长方案体外受精-胚胎移植（IVF/ICSI-ET）周期不同获卵数目与受精率、卵裂率、优质胚胎率、周期冷冻率、移植胚胎数、着床率、临床妊娠率之间的关系。方法：对本院生殖中心2011年1月-2012年12月实施长方案有获卵的共786个IVF/ICSI-ET新鲜周期进行回顾性总结和分析,根据不同获卵数分为五组（A组1~4枚,B组5~10枚,C组11~15枚,D组16~20枚,E组〉20枚）,比较各组年龄、受精率、卵裂率、优质胚胎率、周期冷冻率、移植胚胎数及临床妊娠率。结果：获卵数随年龄增加呈下降趋势,但五组年龄、移植胚胎数比较差异无统计学意义（P〉0.05）;五组受精率、卵裂率、优质胚胎率、冷冻周期率及临床妊娠率比较差异均有统计学意义（P〈0.01）;临床妊娠率C组最高,B、D组较E组高,A组最低,C组优质胚胎率及周期冷冻率均较高。结论：长方案IVF/ICSI-ET周期中,在移植有效胚胎数相同的条件下,获卵数多少与实验室各项指标及临床妊娠率显著相关,获取中等数量的卵子能获得最佳的临床结局。Objective：To investigate and analyze the relationship between different numbers of retrieved oocytes and fertilization rates,cleavage rates,good quality embryos rates,freezing cycle rates,numbers of transferred embryos as well as clinical pregnancy rates in IVF/ICSI cycles.Method：A total of 786 IVF/ICSI-ET cycles performed in the center for reproductive medicine in our hospital from January 2011 to December 2012 were retrospectively summarized and analyzed.The tested women were divided into five groups according to the numbers of retrieved oocytes（group A had 1 to 4 oocytes,group B had 5 to 10 oocytes,group C had 11 to 15 oocytes,group D had 16 to 20 oocytes and group E had more than 20 oocytes）.The age,fertilization rates,cleavage rates,good quality embryos rates,freezing cycle rates,numbers of transferred embryos and clinical pregnancy rates of the five groups were compared.Result：The number of retrieved oocytes was on the decline with the increase of age,but the differences in the age and the numbers of transferred embryos of the five groups were not statistically significant（P〉0.05）.However,the differences in fertilization rates,cleavage rates,good quality embryo rates,freezing cycle rates and clinical pregnancy rates of the five groups were statistically significant（P〈0.01）.Group C had the highest clinical pregnancy rates while group A had the lowest.The clinical pregnancy rates of group B and D were higher than those in group E.Conclusion：In IVF/ICSI cycles,if we have the same number of effectively transferred embryos,the number of retrieved oocytes is closely related to laboratory indexes and clinical pregnancy rates.The best clinical outcome can be reached by obtaining a modest number of oocytes.

关 键 词：获卵数 平均年龄 受精率 卵裂率 冷冻周期率 移植胚胎数 临床妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]