酮洛芬滴丸剂的制备及其体外释放特性  

Preparation and in-vitro release effect of ketoprofen dropping pills

作　　者：王小宁[1] 冯锁民[1] 张存劳 

机构地区：[1]西安医学院药学院,陕西西安710021

出　　处：《化工科技》2015年第6期24-27,共4页Science & Technology in Chemical Industry

基　　金：陕西省教育厅产业化项目(2013JC05);2014陕西省大学生创新创业训练项目(201408030045)

摘　　要：以滴丸成形性为评价指标,筛选了酮洛芬滴丸的制备工艺;以体外释放度为评价指标,优化了滴丸的处方。结果表明,酮洛芬滴丸剂的最优制备工艺为:冷却液为二甲基硅油,冷却液温度0℃,滴速20滴/min,滴距为10cm;最优处方为m(酮洛芬)∶m(PEG6000)=1∶3,并添加崩解剂羧甲基淀粉钠w(CMS-Na)=10%和增溶剂w(吐温-80)=5%;制备的滴丸在20min时体外释放度即达到89.37%,30min时达到98.64%。Selected the formability of drop pills as evaluation index to optimize preparation lected the process of in-vitro release as evaluation index to optimize the prescription. The optimal ketoprofen pills are as follows：the coolant was process. Se- preparation dimethyl silicone oil,with the cooling tern-perature 0 ℃, the tion was PEG6000 tor and Tween 80 dripping speed as the matrix as solubilizer. 20 drops/min and the dripping distance 10 cm. The and drug：matrix proportion was 1 ： 3 with CMS-Na The in-vitro dissolution rate was 98.64% during 30 optimal formula- as the disintegra- rain by the disso-lution test.

关 键 词：酮洛芬 滴丸剂 制备 体外释放 

分 类 号：TQ469[化学工程—制药化工] R944.9[医药卫生—药剂学]