液固压缩技术速释黄芩苷固体自微乳化制剂性质及机理探究  

Investigation of Properties and Immediate-release Mechanism of Baicalin SSMEDDS Based on Liquisolid Compacts Technique

作　　者：周维[1] 李小芳[1] 向志芸 李培培[1] 李平[1] 林浩[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室--省部共建国家重点实验室培育基地,四川成都611137

出　　处：《亚太传统医药》2016年第3期39-42,共4页Asia-Pacific Traditional Medicine

基　　金：四川省教育厅重点项目(15ZA0094)

摘　　要：目的:探讨液固压缩技术使黄芩苷固体自微乳化制剂快速溶出的机制。方法:采用液固压缩技术制备黄芩苷固体自微乳化制剂,比较其与原料药及市售片的溶出度,通过差示扫描量热法(DSC)、粉末接触角测定仪等探讨黄芩苷固体自微乳化制剂的速释机制。结果:黄芩苷固体自微乳化制剂溶出50%,仅需要6.4min。DSC表明黄芩苷固体自微乳化制剂中无黄芩苷的特征峰,黄芩苷固体自微乳粉末的接触角比原料药及市售片明显变小。结论:采用液固压缩技术制备黄芩苷固体自微乳化制剂,可改善药物润湿性,增加药物溶出时的有效表面积,使难溶性药物快速溶出。Objective： To investigate rapid dissolution mechanism of Baicalin SSMEDDS by liquisolid compacts technique. Meth- odS：Baicalin SSMEDDS were prepared by liquisolid compacts technique. Dissolution rate of Baicalin SSMEDDS and crude drug, common tablets were compared. The mechanism of improving dissolution rate of Baicalin SSMEDDS was investigated by differential scanning calorimetry（DSC） and contact angles machine of powders. Results ： Baicalin SSMEDDS that in the dissolution of 50 %, only 6.4rain. DSC showed that the characteristic peaks of drug in Baicalin SSMEDDS had vanished. The contact angle of Baicalin SSMEDDS powders was decreased compared with crude drug and common tablets. Conclusion： Liquisolid compacts technique can increase effective surface area of drugs dissolution and improve drugs wetting properties, then allow rapid dissolution of poorly soluble drugs.

关 键 词：黄芩苷 固体自微乳化释药系统 液固压缩技术 接触角 

分 类 号：R283.6[医药卫生—中药学]