重症急性胰腺炎患者肠屏障功能障碍与血流感染的关系研究  

Relationship between intestinal barrier dysfunction and bloodstream infection of patients with severe acute pancreatitis

作　　者：陈力[1,2] 卢燕[1] 

机构地区：[1]重庆市巴南区人民医院感染消化科,401320 [2]重庆医科大学附属儿童医院急诊科,400014

出　　处：《检验医学与临床》2015年第A02期33-35,共3页Laboratory Medicine and Clinic

摘　　要：目的：研究重症急性胰腺炎患者肠屏障功能障碍与血流感染的关系。方法统计分析2012年5月至2015年5月本院收治的重症急性胰腺炎患者80例的临床资料。结果合并血流感染组患者的 APACHE Ⅱ评分显著高于非血流感染组（P＜0．05），住 ICU 时间显著长于非血流感染组（P＜0．05），4周病死率15．0％（6／40）显著低于非血流感染组5．0％（2／40）（P＜0．05）；合并血流感染组和非血流感染组患者入院后第1、3、7d 的 L／M 、ET 、累及器官数之间的差异均显著（P＜0．05）；合并血流感染组患者入院后第1、3、7d 的 L ／M 、ET 均逐渐升高，非血流感染组患者入院后第1、3、7d 的 L／M 、ET 均逐渐降低，L ／M 、ET 呈显著的正相关关系（P＜0．05）。结论重症急性胰腺炎患者肠屏障功能障碍与血流感染密切相关，值得临床充分重视。Objective To study the relationship between intestinal barrier dysfunction and bloodstream infec‐tion of patients with severe acute pancreatitis .Methods The clinical data of 80 cases of patients with severe acute pancreatitis in our hospital from May 2012 to May 2015 were statistically analyzed .Results The APACHE Ⅱ score of combined bloodstream infections group was significantly higher （P〈 0 .05） ,the duration of ICU stay was signifi‐cantly longer （P〈 0 .05） ,the 4‐week mortality rate 15 .0% （6 / 40） was significantly lower than non bloodstream in‐fection group 5 .0% （2/40） （P〈 0 .05） ;The differences of L / M ,ET ,involving the number of organs after admis‐sion 1 ,3 ,7 d between the combined bloodstream infections group and non bloodstream infection group were signifi‐cant （P〈 0 .05） ;The L / M ,ET after admission 1 ,3 ,7 d of the combined bloodstream infections group were gradual‐ly increased ,The L / M ,ET after admission 1 ,3 ,7d of the non bloodstream infection group decreased gradually ,L /M ,ET showed significant positive correlation （P〈 0 .05） .Conclusion The intestinal barrier dysfunction of patients with severe acute pancreatitis is closely related to bloodstream infection ,so is worthy of the clinical′s full attention .

关 键 词：重症急性胰腺炎 肠屏障功能障碍 血流感染 关系 

分 类 号：R657.51[医药卫生—外科学]