基于甲壳素的手性分离材料  

Chiral Separation Materials Based on Chitin

作　　者：王雯静[1] 桑秋章[1] 邵宇[1] 史伯安[1] 李国祥[1] 

机构地区：[1]湖北民族学院化学与环境工程学院,生物资源保护与利用湖北省重点实验室,恩施445000

出　　处：《材料导报》2016年第1期53-60,共8页Materials Reports

基　　金：国家自然科学基金(51563007);生物资源保护与利用湖北省重点实验室开放基金(PKLHB1522)

摘　　要：甲壳素是一种丰富的可再生资源,将甲壳素在碱性条件下脱去乙酰基得到壳聚糖,甲壳素和壳聚糖分子骨架有大量的手性碳原子存在,且含有较多的羟基、乙酰氨基或氨基活性官能团,容易进行化学改性得到有较好手性识别能力的衍生物,且它们能以膜、纤维、凝胶及微球等不同形式出现,可作为各种手性分离介质。概述了近年来甲壳素衍生物作为手性分离介质的重要研究进展,主要包括甲壳素及其衍生物的色谱手性固定相、手性分离膜、分子印迹聚合物。重点介绍了这些手性分离介质的结构、制备及性能,并展望了甲壳素衍生物手性分离介质的研究前景。Chitin is an abundant and renewable resource. Chitosan is one of the most important derivatives of chitin, derived by removal of acetyl groups under alkaline conditions. The skeleton structures of chitin and chitosan contain a large number of chiral carbon atoms, which are very important for chiral separation. There are many hydrox- yl groups, acetyl amino or amide groups on molecular chains of chitin and chitosan. Some derivatives with better chiral recognition ability can be obtained through chemical modification for reactive groups. Chitin derivatives have different forms, including membranes, fibers, gels and microspheres, which could be used as chiral separation medium. The progress of chitin derivatives as chiral separation medium in recent years is summarized, including the chiral stationary phases of high performance liquid chromatography and capillary electrochromatography, the chiral separation mem- branes, and the molecular imprinted polymers, with emphasis on the structure, preparation and properties of the chiral separation medium. Finally, a perspective on the chitin chiral separation medium and the research directions in the future are briefly discussed.

关 键 词：甲壳素 化学改性 手性识别 手性分离 

分 类 号：O636.9[理学—高分子化学]