基于数据挖掘的肝瘟病阳黄-阴阳黄-阴黄辨证模式用药规律研究  

Study on the Drug Laws of Liver Plague by Yang Huang-Yinyang Huang-Yin Huang Syndrome Differentiation Mode based on Data Mining

作　　者：王国栋[1] 陈斌[1] 王若宇[1] 叶锡勇[1] 彭杰[1] 刘璇[1] 

机构地区：[1]湖南中医药大学第一附属医院国家肝病中医医疗中心,湖南长沙410007

出　　处：《湖南中医药大学学报》2016年第1期78-80,共3页Journal of Hunan University of Chinese Medicine

基　　金：国家中医药行业科研专项"全国中医医疗与临床科研信息共享的推广应用研究"(201207001)

摘　　要：目的总结"阳黄-阴阳黄-阴黄"辨证模式治疗肝瘟病用药规律。方法基于"中医临床科研信息一体化技术平台",制定纳入和排除标准,规则化处理后建立肝瘟病用药数据库,采用频数分析、复杂网络分析、点式互信息等分析方法进行数据挖掘。结果肝瘟病总体用药频次依次为:茵陈(1 368),赤芍(1 309),丹参(1 250),甘草(1 086),白术(1 038)等;其中阳黄证以茵陈(1 062),赤芍(1 016),丹参(970),甘草(823),石菖蒲(796),白术(760)等为主;阴阳黄证以茵陈(285),赤芍(272),白术(268),丹参(260),薏苡仁(245)等为主。核心用药中阳黄证为茵陈、赤芍、丹参;阴阳黄证为白术、茵陈、薏苡仁、附子、丹参、赤芍。阳黄、阴阳黄阶段即开始配伍自术、附子等温阳药物。结论肝瘟病用药总以清热利湿解毒、凉血活血化瘀、益气健脾为主。阳黄证以清热利湿解毒、凉血化瘀为主,阴阳黄证以温阳健脾、活血退黄为主,早期应用温法干预治疗可延缓阴黄化进程。Objective To summarize the law of the treatment of liver plague by ＂Yang Huang-Yinyang Huaug-Yin Huang＂ syndrome differentiation mode. Methods Based on the unified clinical and research information technology platform, the inclusion and exclusion criteria were made, and the drug use database of liver plague was established after regularization processed, using frequency analysis, complex network analysis, point mutual information analysis to data mining. Results Overall drug use frequency of liver plague, in turn, as below： Yinchen （1368）, Chishao （1309）, Danshen （1250）, Gancao （1086）, Baizhu （1038）; Yanghuang syndrome type followed： Yinchen （1062）, Chishao （1016）, Danshen （970）, Gancao （823）, Shichangpu （796）, Baizhu （760）; Yinyanghuang syndrome type followed： ＂Yinchen （285）, Chishao （272）, Baizhu （268）, Danshen （260）, Yiyiren （245）. The core drug use of Yanghuang were Yinchen, Chishao, Danshen, Yinyang Huang were Baizhu, Yinchen, Yiyiren, Fuzi, Danshen, Chishao. At the stage of Yang Huang and Yinyang Huang syndrome type, the compatibility warm drugs, such as Baizhu and Fuzi, were prepared. Conclusion Liver plague medication always take clearing heat-dampness and detoxification, cooling blood and removing stasis, nourishing Qi and spleen as the principle law. Yang Huang syndrome type take as clearing heat-dampness and detoxification, cooling blood and removing stasis, and Yinyang Huang always warming-Yang and strengthening spleen, activating blood and removing jaundice. The interventional treatment of warm therapy can delay the process of Yin Huang.

关 键 词：肝衰竭 肝瘟病 阳黄证 阴阳黄证 用药规律 茵陈 赤芍 白术 丹参 

分 类 号：R256.4[医药卫生—中医内科学]