间质性肺疾病患者呼出气冷凝液中8-异前列腺素及白三烯B4的水平及临床意义  

Levels of 8-isoprostane and leukotriene B4 in exhaled breath condensate and its clinical significance in interstitial lung disease

作　　者：黄立霞[1] 李小莉[1] 黄晓星[2] 巫翠华[1] 洪永忠[1] 钟春[1] 朱一鑫 

机构地区：[1]广东医学院附属南山医院呼吸内科,深圳518052 [2]广东省梅州市人民医院RICU,广东梅州514021

出　　处：《中国当代医药》2016年第3期34-36,共3页China Modern Medicine

基　　金：广东省深圳市科技计划项目(201203208)

摘　　要：目的 探讨间质性肺疾病（ILD）患者呼出气冷凝液（EBC）中8-异前列腺素（8-iso-PG）及白三烯B4（LTB4）的水平及其临床意义。方法 选取2012年8月~2013年12月在我科住院的20例ILD患者为ILD组,20例年龄、性别、体重指数等均相匹配的健康体检者为对照组,采用ELISA检测EBC中8-iso-PG及LTB4水平。结果ILD组EBC中8-iso-PG水平为（9.69±2.8）ng/L,高于对照组的（4.86±1.9）ng/L,差异有统计学意义（P〈0.05）;ILD组EBC中LTB4水平为（15.46±6.6）ng/L,高于对照组的（8.55±4.4）ng/L,差异有统计学意义（P〈0.01）。8-iso-PG、LTB4的特异度均为85%,敏感度分别为90%、60%。结论 8-iso-PG及LTB4在ILD患者EBC中升高,测定EBC生物标志物或可用于评价ILD炎症反应。Objective To investigate the levels of 8-isoprostane（8-iso-PG） and leukotriene B4（LTB4） in exhaled breath condensate（EBC）and its clinical significance in interstitial lung disease（ILD）. Methods 20 ILD patients in our depart- ment from August 2012 to December 2013 were selected as the ILD group,20 healthy subjects matched with age and body mass index were selected as control group.The levels of 8-iso-PG and LTB4 in EBC were measured by ELISA. Results The level of 8-iso-PG in ILD group was （9.69±2.8） ng/L,which was higher than that in control group（4.86±1.9） ng/L with significant difference （P〈0.05）.The level of LTB4 in EBC of ILD group was （15.46±6.6） ng/L,higher than that in control group （8.55±4.4） ng/L,the difference was statistically significant（P〈0.01）.The specificity of LTB4 and 8-iso-PG was 85% respectively,and the sensitivity was 90% and 60% respectively. Conclusion 8-iso-PG and LTB4 increases in EBC of ILD patients.Measuring biomarkers in EBC may be useful to evaluate inflammatory response of ILD.

关 键 词：间质性肺疾病 呼出气冷凝液 8-异前列腺素 白三烯B4 

分 类 号：R563.13[医药卫生—呼吸系统]