艾灸对恶性肿瘤患者化疗前后生存质量影响的Meta分析  

Meta analysis on moxibustion for QLQ-C30-before and after chemotherapy in patients with malignant tumor

作　　者：卢璐[1] 符文彬[2] 刘月[1] 瞿燕春[3] 王洁[1] 

机构地区：[1]广州中医药大学第二临床医学院,广州医学博士研究生510000 [2]广东省中医院针灸科,广州510000 [3]广东省中医院肿瘤科,广州510000

出　　处：《医学研究生学报》2016年第1期75-82,共8页Journal of Medical Postgraduates

基　　金：广东省中医院中医药科学技术研究专项课题(YK2013B1N04)

摘　　要：目的恶性肿瘤患者的病情及治疗过程严重影响其生存质量。近年来人们开始使用灸法干预治疗,以提高生存质量。文中运用循证医学方法评价艾灸结合化疗对恶性肿瘤患者生存质量的影响。方法通过对中国生物医学文献数据库、中国知网、维普数据库、万方数据库和Pub Med数据库的检索,对符合要求的RCT文献进行Meta分析。结果纳入8个临床试验,共计421例患者。分析表明,在功能领域方面,艾灸结合化疗可显著提高恶性肿瘤患者的躯体、社会、心理、角色功能的分值,治疗组与对照组相比差异有统计学意义(P<0.05);但对于认知功能的分值组间比较,差异无统计学意义[MD=4.86,95%CI(-0.33,10.05),Z=1.84,P=0.07]。在症状领域方面,艾灸结合化疗可降低疲劳、恶心呕吐的分值,治疗组与对照组相比差异有统计学意义(P<0.05);但2组的疼痛评分比较,差异无统计学意义[MD=-13.05,95%CI(-28.04,1.95),Z=1.71,P=0.09]。在6个单一条目中,艾灸结合化疗可以显著降低食欲丧失、失眠、便秘、腹泻的评分,治疗组与对照组相比差异有统计学意义;但对于气促[MD=-9.69,95%CI(-22.13,2.75),Z=1.53,P=0.13]和经济困难[MD=-5.57,95%CI(-15.27,4.14),Z=1.12,P=0.26]的评分,组间比较差异无统计学意义。总体健康水平方面,治疗组分值明显高于对照组[MD=13.56,95%CI(8.72,18.39),Z=5.50,P<0.01],提示治疗组在提升肿瘤患者总体健康水平方面具有明显作用。结论循证医学证据表明,艾灸可改善化疗后不良反应、提高生存质量,但还需要更多的研究数据支持。Objective To assess the influence of moxibustion combined chemotherapy for the quality of life of cancer patients by the evidence-based medicine. Methods The literature and document which met the enrolling requirements were searched with com- puter in PubMed, CNKI, Wanfang, CBM and VIP database, and Meta-analyses were conducted on these RCTs. Results Totally 8 studies were included, involving 421 patients. Analysis shows that in functional fields, moxibustion combined with chemotherapy can sig- nificantly improve patients with malignant tumor of scores of physical, social, psychological, role function, the experimental group com- pared with control group with significant statistical significance, but the score of cognitive function compared with control group, there is no statistical significance （ MD = 4.86, 95% CI [ 0. 33, 10.05 ], Z = 1.84, P = 0.07 ） ; In the fields of symptoms, moxibustion com- bined with chemotherapy can reduce the scores of fatigue, nausea and vomiting, the experimental ~TOUp compared with the control group with significant statistical significance, but the pain score of no statistical significance （ MD = 13.05, 95% CI [ 28.04, 1.95 ], Z = 1.71, P = 0. 09）; In six single question, moxibustion combined with chemotherapy can significantly reduce the scores of loss of appetite, in- somnia, constipation, diarrhea, The results of the experimental group compared with the control group was statistically significant, but for the scores of shortness of breath （MD =9.69, 95% CI [22.13, 2.75], Z = 1.53, P = 0.13） and the economic difficuhies （ MD = 5.57, 95% CI [ 15.27, 4.14], Z = 1.12, P = 0.26） ,there is no statistical significance between the two groups ;About scores of overall health level, the experimental group was obviously higher than control group, MD = 13.56, 95% CI [ 8.72, 18.39 ], Z = 5.50, P 〈 0.01, which indicate that comparing of the two groups have signifieant statistical significance. Conclusion Moxibustion can relieve the adverse reaction after chemotherapy, improv

关 键 词：艾灸 恶性肿瘤 QLQ-C30 META分析 

分 类 号：R245[医药卫生—针灸推拿学]