胚胎停育影响因素的Meta分析  

Meta-analysis of risk factors related to the induction of embryo damage

作　　者：郭立燕[1] 翟敏[1] 王莎莎[1] 张妍[1] 

机构地区：[1]济宁医学院公共卫生学院,山东济宁272067

出　　处：《中国儿童保健杂志》2016年第2期166-169,共4页Chinese Journal of Child Health Care

基　　金：山东省高等学校科技计划资助经费项目(J13LK11);济宁市科技计划(医药卫生)项目(2012jnzh10)

摘　　要：目的利用Meta分析方法探讨影响妇女胚胎停育的危险因素,为防治措施的制定提供理论依据。方法通过文献检索收集有关胚胎停育病例对照研究的文献,采用随机效应模型和固定效应模型通过Review Manager 5.2软件进行综合定量分析评价。结果纳入文献37篇,累计病例组7 223例,对照组6 689例;有统计学意义的因素及其合并OR（95%CI）：沙眼衣原体8.46（5.84~12.25）、解脲支原体6.13（4.45~8.43）、沙眼衣原体与解脲支原体混合感染5.90（3.77~9.25）、电磁辐射4.83（3.63~6.44）、被动吸烟4.27（3.76~4.85）、家庭装修2.11（1.76~2.54）、妊娠焦虑1.42（1.25~1.59）;婚检0.60（0.51~0.71）、体育锻炼0.45（0.35~0.57）。结论沙眼衣原体、解脲支原体、沙眼衣原体与解脲支原体混合感染、电磁辐射、被动吸烟、家庭装修是胚胎停育的危险因素,婚检、体育锻炼则是胚胎停育的保护性因素。Objective To investigate the risk factors related to the induction of embryo damage with meta-analysis and to provide theoretic evidence for the exploration and prevention. Methods References related to embryo damage were retrieved and collected with case-control study.Mantel-Haensel fixed effect model and Dersimonian-Laird random effect model were used to perform meta-analysis by Review Manager 5.2. Results Thirty-seven articles which included 7 223 cases in embryo damage group and 6 689 cases in control group were synthetically and quantitatively analyzed by Meta-analysis.The factors with odds ratios and 95%confidence intervals in descending order were Chlamydia trachomatis 8.46（5.84~12.25）,Mycoplasma urealytium 6.13（4.45~8.43）,Chlamydia trachomatis and mycoplasma urealytium 5.90（3.7 7~9.25）,radiation 4.83（3.63~6.44）,smoking passively 4.27（3.76~4.85）,home decoration 2.11（1.76~2.54）,pregnancy anxiety 1.42（1.25~1.59）;pre-marital check-up 0.60（0.51~0.71）,physical exercise 0.45（0.35~0.57）.All these factors were statistically significant. Conclusion Chlamydia trachomatis,Mycoplasma urealytium,radiation and smoking passively were considered to be risk factors of embryo damage,while pre-marital check-up and physical exercise might be associated with protective factors.

关 键 词：胚胎停育 稽留流产 影响因素 META分析 

分 类 号：R179[医药卫生—妇幼卫生保健]