血清胃饥饿素在法洛四联症患儿心肌缺氧炎症反应中的作用  

Role of serum ghrelin on myocardial hypoxia inflammation in children with tetralogy of Fallot

作　　者：赵小洁[1] 耿玉兰[1] 赵景[1] 陈正立[1] 李小兵[2] 李梅[3] 

机构地区：[1]河北医科大学第一医院检验科,河北石家庄050031 [2]河北医科大学第一医院心脏诊疗中心,河北石家庄050031 [3]河北省儿童医院检验科,河北石家庄050031

出　　处：《中国儿童保健杂志》2016年第2期188-191,共4页Chinese Journal of Child Health Care

基　　金：河北省卫生厅科研立项(20110316)

摘　　要：目的探讨血清胃饥饿素(ghrelin)和超敏C反应蛋白(high-sensibivity CRP,hs-CRP)在法洛四联症(tetralogy of Fallot,TOF)患儿心肌缺氧炎症反应中的作用。方法收集本院心脏诊疗中心2012年1月-2014年5月期间60例青紫型TOF患儿及30例同期健康体检儿童静脉血,检测血清ghrelin和hs-CRP浓度。比较两组儿童ghrelin和hsCRP水平并进行相关性分析。结果 TOF患儿组血清ghrelin和hs-CRP水平显著高于正常对照组(P<0.01),且两者呈正相关(P<0.01)。结论法洛四联症患儿血清ghrelin和hs-CR水平升高且呈正相关,提示ghrelin在法洛四联症患儿缺氧导致的心肌炎症反应中具有一定的保护作用。Objective To investigate the roles of both serum ghrelin and high-sensibivity CRP（hs-CRP）on myocardial hypoxia inflammation in children with tetralogy of Fallot（TOF）. Method Serum which were collected from children with TOF（TOF group,n=60）from our Diagnosis and Treatment Center of Congenital Heart Disease from January,2011 to May,2015 and healthy children（control group,n=30）in the same period were examined for ghrelin and hs-CRP.Serum concentrations of both ghrelin and hs-CRP of two groups were compared while their correlation were analyzed. Result The levels of both ghrelin and hs-CRP in children with TOF groups were significantly higher than these in controls（P〈0.01）,and ghrelin had positive correlation with hs-CRP. Conclusion Serum ghrelin in children with TOF is positively correlated with serum hs-CRP,which suggests that serum ghrelin plays certain protection role on myocardial hypoxia inflammation in children with TOF.

关 键 词：法洛四联症 先天性心脏病 胃饥饿素 超敏C反应蛋白 

分 类 号：R179[医药卫生—妇幼卫生保健]