莫西沙星与左氧氟沙星对下呼吸道感染患者白细胞及C反应蛋白水平的影响  

Influences of moxifloxacin and levofloxacin on WBC and CRP levels of patients with LRTI

作　　者：刘传文[1] 杨国青[1] 于法明[1] 

机构地区：[1]濮阳市油田总医院,河南濮阳457001

出　　处：《临床心身疾病杂志》2016年第1期1-3,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨莫西沙星与左氧氟沙星对下呼吸道感染患者血清白细胞及C反应蛋白水平的影响。方法将72例下呼吸道感染患者按照随机数字表法分为两组，每组36例，观察组予以莫西沙星治疗，对照组予以左氧氟沙星治疗，观察7d。治疗前后检测两组血清白细胞及C反应蛋白水平的变化，随时记录临床症状消失时间及不良反应发生状况。结果治疗后两组血清白细胞及C反应蛋白水平均较治疗前显著下降（P〈O．01），但观察组总有效率（94．4％）显著高于对照组（77．8％）（χ2=4．18，P〈o．05），发热、咳嗽、肺部罗音l临床症状消失时间显著快于对照组（P〈O．05或0．01）；观察组不良反应发生率为5．6％，对照组为8．3％，两组比较差异无显著性（χ2=o．22，P〉O．05）。结论莫西沙星与左氧氟沙星均能显著降低下呼吸道患者血清白细胞及C反应蛋白水平，但莫西沙星缓解临床症状快，疗效更显著，安全性高，较左氧氟沙星更具有优势。Objective To explore the influences of moxifloxacin and levofloxacin on white blood cell （WBC） and C-reactive protein （CRP） levels of patients with lower respiratory tract infection （LRTI）. Methods Seventy-two LRTI patients were assigned to two groups of 36 ones each according to random number table, research group was treated with moxifloxacin and control group with levofloxacin for 7 days. WBC and CRP changes were detected before and after treatment, extinction time of symptoms and adverse reactions status recorded any time. Results After treatment WBC and CRP levels of both groups lowered more significantly compared with pretreatment （P〈0.01）, total effective rate was significantly higher （94.4% vs. 77.8%,χ2 =4.18,P〈0.05） and the extinction of fever, cough and lung rale quicker （P〈0.05 or 0.01） in research than in control group; the incidence of adverse reactions was 5.6% in re- search and 8. 3% in control group, which showed no significant difference （χ2= 0. 22, P〈0. 05）. Conclusion Both moxifloxacin and levofloxacin can significantly decrease the WBC and CRP levels of LR- TI patients, but moxifloxacin takes effect more rapidly and has an evident effect and higher safety com- pared with levofloxacin.

关 键 词：下呼吸道感染 抗生素 莫西沙星 左氧氟沙星 白细胞计数 C反应蛋白 

分 类 号：R56[医药卫生—呼吸系统] R453.2[医药卫生—内科学]