人脂肪间充质干细胞治疗心肌梗死的研究进展  

Advances in adipose–derived mesenchymal stem cell for treatment of myocardial infarction

作　　者：相杭[1] 曾强[1] 

机构地区：[1]解放军总医院健康管理研究院,北京100853

出　　处：《解放军医学院学报》2016年第1期91-95,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家科技支撑计划(2012BAI37B04)~~

摘　　要：脂肪间充质干细胞是一类具有再生和多向分化潜能的多能干细胞。既往研究已经证实,人脂肪间充质干细胞移植能够有效地促进心肌梗死后的心肌再生和微血管生成,从而改善心功能并减轻心室重塑。本文主要回顾了多种来源的人脂肪间充质干细胞的生理学特性和修复特性,并对其在心肌梗死方面的实验及临床研究加以综述,旨在为将来的临床应用提供参考依据。Human adipose mesenchymal stem cells（h ADMSCs） are regenerative and multi-differentiation potential stem cell. Previous studies have demonstrated that h ADMSCs transplantation can effectively promote myocardial regeneration and angiogenesis after myocardial infarction, by improving the heart function and ventricle remolding remarkably. This review introduces the physical characteristics and reparative function of h ADMSCs, which derives from different sources. Furthermore, the application of h ADMSCs for experiment researches and clinical trials are also summarized in this article, in order to provide fundamental basis for their clinical use.

关 键 词：脂肪组织 间充质干细胞 心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]