蓝布正对大脑供血供氧及止血耐眩晕作用的影响  

Study on Geum japonicum Thunb. var chinense F. Bolle improving blood and oxygen supply to the brain and effects of hemostasis and anti-vertigo

作　　者：刘杨[1] 邓颖[1] 刘明[1] 陈凤彩[1] 江蓓 吕金田 蔡兵 

机构地区：[1]贵阳中医学院基础医学院,贵阳550025 [2]贵州盛世龙方制药股份有限公司,贵阳550001

出　　处：《中药药理与临床》2015年第6期97-100,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：贵州省教育厅项目(黔教合协同创新字[2013]02号);贵州省科技厅项目(黔科合重G字[2012]4001号);贵阳中医学院院内项目(NO:20140710)

摘　　要：目的:实验观察蓝布正促进大脑供血供氧、止血、耐眩晕作用。方法:将小鼠分为空白对照组、蓝布正组(10.0g/kg、5.0g/kg、2.5g/kg)、天保宁组(0.01g/kg)进行断头后张口喘气实验、耐常压缺氧实验;将大鼠分为空白对照组、蓝布正组(7.00g/kg、3.50g/kg、1.75g/kg)、天保宁组(0.007g/kg),双侧颈总动脉结扎后测量大脑含水量;将豚鼠分为空白对照组、蓝布正组(5.00g/kg、2.50g/kg、1.25g/kg)、氟桂利嗪组(0.008g/kg),进行氯仿致眩晕实验;将小鼠分为空白对照组、蓝布正组(10.0g/kg、5.0g/kg、2.5g/kg)、氟桂利嗪组(0.002g/kg),经机械致眩晕后进行水迷宫测试;将小鼠分为空白对照组、蓝布正组(10.0g/kg、5.0g/kg、2.5g/kg)、云南白药组(0.2g/kg),完成止血试验。结果:蓝布正组(10.0g/kg)在断头后张口喘气试验和耐常压缺氧试验中具有显著差异;蓝布正组(7.00g/kg、3.50g/kg、1.75g/kg)及天保宁组(0.007g/kg)在双侧颈总动脉结扎后具有不同程度减轻由缺血引起的脑水肿作用;蓝布正组(5.00g/kg、2.50g/kg、1.25g/kg)和氟桂利嗪组(0.008g/kg)在对氯仿致眩晕实验中都具有程度不同的耐受作用;蓝布正组(5.0g/kg)在机械致眩晕后进行水迷宫测试中有显著差异;蓝布正组(10.0g/kg、5.0g/kg、2.5g/kg)和云南白药组(0.2g/kg)在出血后止血方面有一定的止血作用,止血效果因出血部位的不同而存在差异。结论:蓝布正有改善对大脑供血供氧及止血耐眩晕的作用。Objective： The experiment is to observe the effects of Geum japonieum Thunb. var chinense F. Bolle in terms of promoting blood and ox- ygen supply, stopping bleeding and anti-vertigo. Methods： A total of 60 mice were divided into control group, Geum japonicum Thunb. var chinense F. Bolle groups （ 10.0g/kg,5.0g/kg,2.5 g/kg） and Tianbaoning group （ 0.01 g/kg）. They were carried out bearing hypoxia at normal pressure experiment and hollow gasp experiment after cutting head;A total of 72 rats were divided into control group, Geum japonicum Thunb. var chinense F. Bolle groups （ 7.00g/kg, 3.50g/kg, 1.75g/kg） and Tianbaoning group （ 0. 007g/kg）. They were carried out experiment of measuring brain water content after ligation of bilateral common carotid arteries ; A total of 50 cavia cobaya were divided into control group, Ge- um japonicum Thunb. var chinense F. Bolle groups（5.00g/kg,2.50g/kg, 1.25g/kg） and Flunarizine group（0.008g/kg）. They were carried out chloroform-induced vertigo experiment ;A total of 70 mice were divided into control group, Geum japonicum Thunb. var chinense F. Bolle groups（10.0g/kg,5.0g/kg,2.5g/kg） and Flunarizine group（0.002g/kg）. They were carried out water maze test after vertigo induced by me- chanical; A total of 60 mice were divided into control group, Geum japonicum Thunb. var chinense F. Bolle groups （ 10.0g/kg,5.0g/kg, 2.5g/ kg） and Yunnan White group （0.2g/kg） to complete tests of hemostatic function. Results： Geum japonicum Thunb. vat chinense F. Bolle group（10.0g/kg） has the remarkable difference in bearing hypoxia at normal pressure experiment and hollow gasp experiment after cutting head （ P 〈 0.01 ） ; Geum japonicum Thunb. var chinense F. Bolle groups （ 7. O0g/kg, 3.50g/kg, 1.75 g/kg） and Tianbaoning group （ 0. 007 g/ kg） were different degrees relieving of brain edema caused by ischemia effect;Geum japonicum Thunb. var chinense F. Bolle groups （5.00g/ kg,2.50g/kg,1.25g/kg） and Flunarizine group（0. 008g/kg）were

关 键 词：蓝布正 供血供氧 止血 耐眩晕 

分 类 号：R285.5[医药卫生—中药学]