2014年天津市肠道病毒所致疱疹性咽峡炎临床流行病学分析  

The analysis of clinical epidemiological characteristics of herpangina by enterovirus in Tianjin City,2014

作　　者：李佳萌[1] 李琳[1] 吕莉琨[1] 高璐[1] 李力[1] 赵卓[2] 

机构地区：[1]天津市疾病预防控制中心传染病科,天津300011 [2]辽宁省疾病预防控制中心办公室,辽宁沈阳110005

出　　处：《中华疾病控制杂志》2016年第1期26-29,共4页Chinese Journal of Disease Control & Prevention

基　　金："十二五"国家科技重大专项(2012ZX10004209);天津市卫生局科技基金(2014KZ044)

摘　　要：目的探讨天津市疱疹性咽峡炎的发生情况及其流行特征。方法采集了134例疱疹性咽峡炎患者中的133份咽拭子标本和54份粪便标本并进行肠道病毒(enterovirus,EV)检测,同时入户对所有患者进行流行病学调查。结果 134例疱疹性咽峡炎患者EV阳性率为64.93%,其中柯萨奇病毒A10(coxsackie virus A10,Cox A10)占34.48%、柯萨奇病毒A16(coxsackie virus A16,Cox A16)占29.89%。咽拭子标本的阳性率和粪便标本的阳性率一致性较高(Kappa值=0.709,P<0.001)。临床症状中发热、咽痛、呕吐、惊厥的比例均高于同期手足口病患者(均有P<0.05)。不同月疱疹性咽峡炎的主要流行病原不同(2=28.652,P<0.001),且与同期手足口病流行的主要病原不同(均有P<0.05),但总体上病原种类一致。结论作为肠道病毒传染源之一的疱疹性咽峡炎患者应与手足口病一起纳入监测管理。Objective To study the incidence and epidemiological characteristics of herpangina in Tianjin. Meth- ods A total of 134 herpangina cases were investigated, 133 throat swabs and 54 stool samples were tested. Results En- terovirus positive rate of 134 herpangina cases was 64. 93% , of which coxsackie virus A10 accounted for 34. 48% , and coxsackie virus A16 accounted for 29.89%. The pan-enterovirus positive rate of stool samples were in accordance with the rate of throat swabs （ Kappa = 0. 709,P 〈 0. 001 ）. The proportion of some symptoms including fever, sore throat, vomit and convulsions was higher in herpangina patients than in the hand-foot-mouth disease cases （all P 〈 0. 05）. The major epi- demic enterovirus of herpangina was different among different month （ x^2 = 28. 652, P 〈 0. 001 ）. Although there were difference between herpangina and hand-foot-mouth disease in major epidemic enterovirus （ all P 〈 0. 05 ） , the types of en- terovirus were consistent. Conclusions As one of enterovirus infection source, herpangina patients should be included in the monitoring and management together with hand-foot-mouth disease.

关 键 词：疱疹性咽峡炎 流行病学 手足口病 

分 类 号：R181[医药卫生—流行病学] R766.12[医药卫生—公共卫生与预防医学]