儿童缺铁性贫血与血铅水平关系的Meta分析  

Association between iron deficiency anemia and blood lead level in children: a Meta-analysis

作　　者：旷满华 杨青廷 翦耀文 熊文婧[2] 高露[1] 让蔚清[1] 

机构地区：[1]南华大学公共卫生学院疾病控制评价中心,湖南衡阳421001 [2]北京中医药大学基础医学院循证医学中心,北京100000

出　　处：《中华疾病控制杂志》2016年第1期79-83,共5页Chinese Journal of Disease Control & Prevention

基　　金："公共卫生与预防医学"湖南省"十二五"重点学科项目建设资助(2011年);"疾病控制评价"南华大学"十二五"校级重点实验室项目建设资助(2012年);2015年湖南省研究生科研创新项目(CX2015B417)

摘　　要：目的应用Meta分析评价儿童缺铁性贫血与血铅水平的关系。方法检索收集2014年12月之前国内外发表的有关儿童缺铁性贫血与血铅水平的文献。应用Stata12．0进行分析，Q检验和，2检验反应异质性大小，亚组分析和敏感性分析探讨异质性来源，采用漏斗图法、Begg秩相关和Egger线性回归法识别发表偏倚。结果共纳入文献7篇，总样本量为l649例，缺铁性贫血组722例，对照组927例。儿童血铅水平合并标准化均数差和95％可信区间（1．18，0．57-1．80），缺铁性贫血组儿童血铅水平高于对照组，差异有统计学意义（Z=3．78，P〈0．001）。结论缺铁性贫血组的儿童血铅水平高于对照组的儿童血铅水平，说明儿童缺铁性贫血与血铅水平有关.Objective To analyze and evaluate the relationship between iron deficiency anemia （IDA） and blood lead level （BLL） in children by using Meta-analysis. Methods Chinese and English literature prior to December 2014 on children with blood lead levels of iron deficiency anemia were searched and collected. Statal2.0 was used for data analysis, Cochrane＇ s Q and I2 statistics were used to evaluate heterogeneity among studies, subgroup analysis and sensitivity analysis were used to explore the heterogeneity sources. Publication bias was calculated by funnel plot, Begg rank correlation test and Egger linear regression test. Results A total of 7 articles were considered and totally 722 cases of iron deficiency ane- mia group and 927 cases in control group were enrolled in the study. The combined ehildren＇s blood lead level of standardi- zation mean difference and 95% confidence intervals SMD （95% CI） was 1.18 （0. 57-1.80） , the results showed that the group of children with iron deficiency anemia blood lead level was higher and the difference was statistically significant （Z = 3, 78 ,P 〈 0. 001 ）. Conclusions Our finding suggests that the blood lead level is correlated with the occurrence of IDA, and the average blood lead level of children with IDA is higher than that of the control group.

关 键 词：儿童 贫血 缺铁性 血铅水平 META分析 

分 类 号：R556.3[医药卫生—血液循环系统疾病] R181.1[医药卫生—内科学]