定量动态增强MRI在脑高低级别胶质瘤术前病理分级中的应用研究  

Evaluation of T1-DCE MRI for the preoperative pathological evaluation of Tumor grade in brain glioma

作　　者：赵明[1] 付旷[1] 郭丽丽[1] 张铁成[1] 周丽[1] 赵荟[1] 张晶[1] 

机构地区：[1]哈尔滨医科大学附属第二医院磁共振成像诊断科,黑龙江哈尔滨150086

出　　处：《中国实验诊断学》2016年第1期42-44,共3页Chinese Journal of Laboratory Diagnosis

基　　金：黑龙江省自然科学基金项目(H201453)

摘　　要：目的探讨定量动态增强MRI(T1-DCE MRI)在脑高低级别胶质瘤术前病理分级中的应用价值。方法选择经手术病理证实的30例脑胶质瘤患者为研究对象,其中低级别(WHOⅠ、Ⅱ级)胶质瘤15例,高级别(WHOⅢ、Ⅳ级)胶质瘤15例。全部病例均行3T常规MR增强及MR灌注成像检查,原始灌注图像数据经工作站软件处理,构建容量转移常数(Ktrans)、回流速率常数(Kep)、血管外细胞外容积分数(Ve)图,选择ROI,计算Ktrans、Kep和Ve值。高低级别胶质瘤Ktrans、Kep和Ve值与病理分级进行Pearson相关性分析。结果 Ktrans、Kep和Ve值与病理学分级具有明显相关性(r=0.934,0.837,0.807)。各参数高低级别胶质瘤患者间比较有明显的统计学差异,随着肿瘤级别的增高,Ktrans、Kep和Ve值增高。结论通过Permeability技术测量肿瘤血管Ktrans、Kep和Ve值,可以了解肿瘤微血管灌注状态,对高低级别胶质瘤进行较为精确的术前分级。Objective To evaluate the value of T1-DCE MRI for the preoperative pathological evaluation of tumor grade in brain glioma. Methods Our study included 30 patients who were pathologically confirmed with a tumor grade between I-IV（WHO Ⅰ and Ⅱ grade 15 cases,WHO Ⅲ and Ⅳ grade 15 cases）. All experiments were examined with MRI and MR perfusion weighted image. The original perfusions imaging data were analyzed by the Philips permeability assessment functool software,which produced the transfer constant （Ktrans） map, the rate constant （Kep） map and frac- tional volume （Ve） map. Choose ROI and get values of Ktrans,Kep and Ve. Pearson correlation was carried out to use the value of different grade glioma and pathology classifications. Results The Ktrans,Kep and Ve values of each levels with pathological grading has a strong correlation（r= 0. 934,0. 837,0. 807）. There is obviously statistically significant differ- ence between different grade groups（P〈0.01）. With higher grade of glioma,the parameters values of Ktrans ,Kcp and Vo increases. Conclusion Through Permeability technology to measure the Ktrans,Kep, and Ve values of gliomas can obtain a relatively accurate quantitative analysis for different grade of glioma before operation.

关 键 词：脑胶质瘤 T1-DCE MRI PERMEABILITY 术前 分级 

分 类 号：R445.2[医药卫生—影像医学与核医学]